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WormBase Tree Display for Variation: WBVar00089142

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Name Class

WBVar00089142EvidencePaper_evidenceWBPaper00024501
NamePublic_namemn391
Other_nameM02B7.3b.1:c.1315C>T
CE31568:p.Gln439Ter
M02B7.3a.3:c.1231C>T
M02B7.3a.2:c.1231C>T
CE31567:p.Gln411Ter
M02B7.3a.1:c.1231C>T
HGVSgCHROMOSOME_IV:g.3797443G>A
Sequence_detailsSMapS_parentSequenceM02B7
Flanking_sequencesgaagaagcggcgaagaagatccaacagctcaagatcagtttattggaggagaagaagcag
Mapping_targetM02B7
Type_of_mutationSubstitutionctPaper_evidenceWBPaper00024501
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00034363
LaboratorySP
StatusLive
AffectsGeneWBGene00003884
TranscriptM02B7.3a.3VEP_consequencestop_gained
VEP_impactHIGH
HGVScM02B7.3a.3:c.1231C>T
HGVSpCE31567:p.Gln411Ter
cDNA_position1475
CDS_position1231
Protein_position411
Exon_number6/11
Codon_changeCaa/Taa
Amino_acid_changeQ/*
M02B7.3a.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScM02B7.3a.1:c.1231C>T
HGVSpCE31567:p.Gln411Ter
cDNA_position1329
CDS_position1231
Protein_position411
Exon_number7/12
Codon_changeCaa/Taa
Amino_acid_changeQ/*
M02B7.3a.2VEP_consequencestop_gained
VEP_impactHIGH
HGVScM02B7.3a.2:c.1231C>T
HGVSpCE31567:p.Gln411Ter
cDNA_position1920
CDS_position1231
Protein_position411
Exon_number7/12
Codon_changeCaa/Taa
Amino_acid_changeQ/*
M02B7.3b.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScM02B7.3b.1:c.1315C>T
HGVSpCE31568:p.Gln439Ter
cDNA_position1315
CDS_position1315
Protein_position439
Exon_number6/10
Codon_changeCaa/Taa
Amino_acid_changeQ/*
GeneticsInterpolated_map_positionIV-2.21384
DescriptionPhenotypeWBPhenotype:0001441Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
RemarkAnimals showed significantly reduced chemotaxis to ammonium acetate compared to wild-type animals.Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00002790Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
Phenotype_assayTreatmentFor the water soluble chemotaxis assay, radial gradients of NH4Ac were established by diffusion in the agar.Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
WBPhenotype:0001484Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
RemarkAnimals showed significantly reduced chemotaxis to ammonium acetate in both the soluble and odorant assays, compared to wild-type animals.Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00002790Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were tested in both soluble and odorant chemotaxis assays. For the soluble assay, radial gradients of NH4Ac were established by diffusion in the agar. For the odorant assay, a droplet of NH4Ac (10 mL, 7.5 M) was suspended from the lid of the plate.Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
WBPhenotype:0002535Paper_evidenceWBPaper00002087
WBPaper00024501
Curator_confirmedWBPerson48
RemarkDefects in dye filling.Paper_evidenceWBPaper00002087
Curator_confirmedWBPerson48
Based on defective dye fillingPaper_evidenceWBPaper00024501
Curator_confirmedWBPerson48
RecessivePaper_evidenceWBPaper00002087
Curator_confirmedWBPerson48
Phenotype_not_observedWBPhenotype:0000663Paper_evidenceWBPaper00024501
Curator_confirmedWBPerson48
ReferenceWBPaper00024501
WBPaper00002087
WBPaper00031959
WBPaper00010097
WBPaper00025332
MethodSubstitution_allele