WormBase Tree Display for Variation: WBVar00088915

WBVar00088915 Evidence: Paper_evidence: WBPaper00004727
  Name: Public_name: mg158
    Other_name: C40H5.5a.1:c.1018T>A
      CE43132:p.Phe312Ile
      CE27107:p.Phe340Ile
      C40H5.5b.1:c.934T>A
    HGVSg: CHROMOSOME_X:g.11764947A>T
  Sequence_details: SMap: S_parent: Sequence: C40H5
    Flanking_sequences: ctcgacggtattttgcacgagcattttgaa ccaaacctggaaacaaaagtagttctggat
    Mapping_target: C40H5
    Type_of_mutation: Substitution: a t Curator_confirmed: WBPerson4055
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00029272
      WBStrain00029472
      WBStrain00029473
      WBStrain00029474
    Laboratory: GR
    Status: Live
  Affects: Gene: WBGene00006654
    Transcript: C40H5.5b.1 (12)
      C40H5.5a.1 (12)
    Interactor: WBInteraction000003412
      WBInteraction000003413
      WBInteraction000003414
      WBInteraction000003415
      WBInteraction000003416
      WBInteraction000521604
      WBInteraction000569171
  Genetics: Interpolated_map_position: X 6.70739
  Description: Phenotype: WBPhenotype:0001278 Paper_evidence: WBPaper00004727
        Curator_confirmed: WBPerson557
        Remark: Animals were defective in autoregulation of a ttx-3prom::gfp reporter gene in the AIY interneuron. In Wildtype the expression is strong, in contrast, expression is mostly undetectable in these mutants. Paper_evidence: WBPaper00004727
            Curator_confirmed: WBPerson557
        Phenotype_assay: Genotype: ttx-3prom::gfp (mgIs18) Paper_evidence: WBPaper00004727
              Curator_confirmed: WBPerson557
      WBPhenotype:0002513 Paper_evidence: WBPaper00004727
        Curator_confirmed: WBPerson557
        Remark: Thermotaxis defects mimic those seen upon laser ablation of the AIY interneurons. Paper_evidence: WBPaper00004727
            Curator_confirmed: WBPerson557
    Phenotype_not_observed: WBPhenotype:0000424 Paper_evidence: WBPaper00004906
        Curator_confirmed: WBPerson2021
        Remark: Mutations affecting fate and function of the AIY and AIZ interneurons have no effect on AWA-specific ODR-7 expression Paper_evidence: WBPaper00004906
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00004906
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: ODR-7 antibody staining Paper_evidence: WBPaper00004906
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001780 Paper_evidence: WBPaper00029060
        Curator_confirmed: WBPerson2021
        Remark: Mutants show normal butanone enhancement Paper_evidence: WBPaper00029060
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00029060
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: Preexposure to 1:10 dilution of butanone and food. Animals were then subjected to odorant chemotaxis assays and/or selection assays Paper_evidence: WBPaper00029060
              Curator_confirmed: WBPerson2021
  Reference: WBPaper00029060
    WBPaper00004906
    WBPaper00004727
  Remark: Variation flanks and nucleotide change automatically updated to be on the positive strand to fix mapping and gff dumping issues.
    [200224 mh6] reverse complemented/swapped the change and flanks to move the variation onto the plus strand Curator_confirmed: WBPerson4055
  Method: Substitution_allele