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WormBase Tree Display for Variation: WBVar00088913

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Name Class

WBVar00088913NamePublic_namemg144
Other_nameC12D8.10c.1:c.547G>A
C12D8.10a.1:c.547G>A
C12D8.10b.1:c.547G>A
CE31304:p.Ala183Thr
CE05274:p.Ala183Thr
CE15612:p.Ala183Thr
HGVSgCHROMOSOME_V:g.10250416G>A
Sequence_detailsSMapS_parentSequenceC12D8
Flanking_sequencesATGATTAGTATTGCTGACACCAGCGAAGCTCTAAAAGAGACAAAATCGTAAGAAAACCTA
Mapping_targetC12D8
Type_of_mutationSubstitutionga
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00007898
LaboratoryGR
StatusLive
AffectsGeneWBGene00000102
TranscriptC12D8.10c.1 (12)
C12D8.10b.1 (12)
C12D8.10a.1 (12)
Interactor (12)
GeneticsInterpolated_map_positionV2.42337
DescriptionPhenotypeWBPhenotype:0000315Paper_evidenceWBPaper00046423
Curator_confirmedWBPerson10425
Remarkreduced sensitivity to gentle touch on the anterior half of the body.Paper_evidenceWBPaper00046423
Curator_confirmedWBPerson10425
PenetranceIncompletePaper_evidenceWBPaper00046423
Curator_confirmedWBPerson10425
RecessivePaper_evidenceWBPaper00046423
Curator_confirmedWBPerson10425
WBPhenotype:0000481Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
Remarkakt-1(mg144) mutant animals display a reduced aversion response to copper, compared to wild type animals (Figure 2B)Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00002862Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
WBPhenotype:0000737Paper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
Remarkakt-1 gain-of-function mutants exhibited reduced sensitivity to DNA-damage-induced germ-cell apoptosis 12, 24, and 36 hr after irradiationPaper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0006796PATO:0000460Paper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
Life_stageWBls:0000041PATO:0000460Paper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentTreated with 60 Gy of IRPaper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
WBPhenotype:0001351Paper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
RemarkThe levels of phosphorylated CEP-1 were lower in akt-1(mg144) than in wild-type worms at all doses of IR testedPaper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000041PATO:0000460Paper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentIR treatmentPaper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
WBPhenotype:0001645Paper_evidenceWBPaper00029116
Curator_confirmedWBPerson1754
RemarkBlocks protein degradation in response to treatment with the AGE-1 inhibitor LY-294002Paper_evidenceWBPaper00029116
Curator_confirmedWBPerson1754
Affected_byMoleculeWBMol:00005384Paper_evidenceWBPaper00029116
Curator_confirmedWBPerson1754
WBPhenotype:0001788Paper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
Remarkakt-1 gain-of-function mutants showed a significant decrease in the number of germ-cell corpses after ENU treatmentPaper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0006796PATO:0000460Paper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
Life_stageWBls:0000041PATO:0000460Paper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentTreated with 5mM ENUPaper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
WBPhenotype:0001806Paper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
RemarkIn akt-1 gain-of-function mutants, the stability of CEP-1 is reducedPaper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000041PATO:0000460Paper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentIR treatmentPaper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
WBPhenotype:0001999Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
RemarkThe integration of signals for attraction to diacetyl (100x dilute) and avoidance from copper (100 millimolar) was impaired in akt-1(mg144) insulin-like signaling pathway mutants, resulting in more animals crossing the copper barrier to get to the diacetyl spot than in wild type controls (Figure 1C)Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00002862Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
WBMol:00002819Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
WBPhenotype:0002256Paper_evidenceWBPaper00044686
Curator_confirmedWBPerson1754
RemarkIncreased sensitivity to selenium induced movement declinePaper_evidenceWBPaper00044686
Curator_confirmedWBPerson1754
Affected_byMoleculeWBMol:00001915Paper_evidenceWBPaper00044686
Curator_confirmedWBPerson1754
Phenotype_not_observedWBPhenotype:0000145Paper_evidenceWBPaper00003173
Curator_confirmedWBPerson712
Remarkmg144 has normal brood sizes.Paper_evidenceWBPaper00003173
Curator_confirmedWBPerson712
WBPhenotype:0000147Paper_evidenceWBPaper00040181
Curator_confirmedWBPerson712
RemarkThe starvation induced ribosome biogenesis was not ablated in the starved male worms. Starvation-enhanced rRNA biosynthesisoccurs in adult males.Paper_evidenceWBPaper00040181
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00040181
Curator_confirmedWBPerson712
WBPhenotype:0000308Paper_evidenceWBPaper00003173
Curator_confirmedWBPerson712
RemarkOn its own mg144 does not have any obvious phenotype. The strain arrests as dauers on starved plates and on plates treated with pheromone.Paper_evidenceWBPaper00003173
Curator_confirmedWBPerson712
WBPhenotype:0000436Paper_evidenceWBPaper00028886
Curator_confirmedWBPerson48
RemarkLocalization of the synaptic protein SNB-1 is normal, based on transgene analysis with a reporter.Paper_evidenceWBPaper00028886
Curator_confirmedWBPerson48
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00028886
Curator_confirmedWBPerson48
WBPhenotype:0000699Paper_evidenceWBPaper00003173
Curator_confirmedWBPerson712
Remarkmg144 has a normal vulva.Paper_evidenceWBPaper00003173
Curator_confirmedWBPerson712
WBPhenotype:0000730Paper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
RemarkNone of the akt mutants affected developmental apoptosisPaper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
WBPhenotype:0000741Paper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
RemarkGermline cell-cycle arrest was not altered in either akt-1 gain-of-function or loss-of-function mutantsPaper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
WBPhenotype:0000885Paper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
RemarkNone of the akt mutants affected the engulfment rates of the germ-cell corpsesPaper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
WBPhenotype:0001470Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
RemarkMutants exhibited no change in chemotaxis towards diacetyl, compared to wild type controls (Figure 2A)Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00002819Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
WBPhenotype:0004023Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
RemarkMutant animals exhibit a wild type frequency of body bends (Figure 3A)Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
ReferenceWBPaper00037970
WBPaper00040181
WBPaper00028886
WBPaper00029085
WBPaper00003173
WBPaper00029116
WBPaper00018509
WBPaper00015792
WBPaper00044686
WBPaper00046423
MethodSubstitution_allele