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WormBase Tree Display for Variation: WBVar00088323

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Name Class

WBVar00088323EvidencePaper_evidenceWBPaper00006388
NamePublic_nameku119
Other_nameF01G12.2a.2:c.-74+1G>A
F01G12.2b.1:c.460+1G>A
F01G12.2a.1:c.-291G>A
HGVSgCHROMOSOME_X:g.16377770G>A
Sequence_detailsSMapS_parentSequenceF01G12
Flanking_sequencesttgaagaggctcatgagcatcccatagctttaggttacctttgaattaaatatcataaaa
Mapping_targetF01G12
Type_of_mutationSubstitutionga
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00026504
LaboratoryMH
StatusLive
AffectsGeneWBGene00006353
TranscriptF01G12.2a.2VEP_consequencesplice_donor_variant
VEP_impactHIGH
HGVScF01G12.2a.2:c.-74+1G>A
Intron_number3/9
F01G12.2b.1VEP_consequencesplice_donor_variant
VEP_impactHIGH
HGVScF01G12.2b.1:c.460+1G>A
Intron_number4/8
F01G12.2a.1VEP_consequence5_prime_UTR_variant
VEP_impactMODIFIER
HGVScF01G12.2a.1:c.-291G>A
cDNA_position473
Exon_number3/9
InteractorWBInteraction000002330
WBInteraction000002974
WBInteraction000002975
WBInteraction000524413
WBInteraction000524414
WBInteraction000524415
WBInteraction000524617
GeneticsInterpolated_map_positionX23.9133
Mapping_dataIn_multi_point4958
DescriptionPhenotypeWBPhenotype:0000671Paper_evidenceWBPaper00006388
Curator_confirmedWBPerson2987
Remarksur-7(ku119) mutant animals exhibited a statistically significant increased tolerance to copper at a concentration of 0.5 millimolar (data not shown)Paper_evidenceWBPaper00006388
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00002862Paper_evidenceWBPaper00006388
Curator_confirmedWBPerson2987
WBPhenotype:0001747Paper_evidenceWBPaper00033166
Curator_confirmedWBPerson2021
RemarkUnlike wild-type, sur-7 mutant animals displayed reduced maturation at low and high concentrations of dietary zincPaper_evidenceWBPaper00033166
Curator_confirmedWBPerson2021
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00033166
Curator_confirmedWBPerson2021
Affected_byMoleculeWBMol:00003477Paper_evidenceWBPaper00033166
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentEggs were transferred to CeMM with 18-19 different concentrations of zinc, ranging from no added zinc to 2 mM zincPaper_evidenceWBPaper00033166
Curator_confirmedWBPerson2021
WBPhenotype:0001749Paper_evidenceWBPaper00006388
Curator_confirmedWBPerson2987
Remarksur-7(ku119) animals were more sensitive to increasing concentrations of zinc than wild type (Figure 2). The progeny of animals placed on metal-supplemented growth media showed increasing sensitivity to zinc concentrations at and above 0.25 millimolar as assayed by their rate of developmental maturation. These differences were found to be significant at and above 1.0 millimolar zinc (student's t-test: a 0.05).Paper_evidenceWBPaper00006388
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00005064Paper_evidenceWBPaper00006388
Curator_confirmedWBPerson2987
WBPhenotype:0001849Paper_evidenceWBPaper00033166
Curator_confirmedWBPerson2021
Remarksur-7 mutant animals displayed dramatic growth defects and relatively normal zinc content suggesting that the distribution of zinc is abnormal in mutant animalsPaper_evidenceWBPaper00033166
Curator_confirmedWBPerson2021
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00033166
Curator_confirmedWBPerson2021
Affected_byMoleculeWBMol:00005064Paper_evidenceWBPaper00033166
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentDetermination of zinc content of C. elegans using inductively coupled plasma-mass spectrometry (ICP-MS)Paper_evidenceWBPaper00033166
Curator_confirmedWBPerson2021
Phenotype_not_observedWBPhenotype:0001175Paper_evidenceWBPaper00048917
Curator_confirmedWBPerson721
WBPhenotype:0001272Paper_evidenceWBPaper00006388
Curator_confirmedWBPerson2987
RemarkIn an otherwise wild-type background, sur-7(ku119) exhibits no obvious vulva underinduction defects.Paper_evidenceWBPaper00006388
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0007809PATO:0000460Paper_evidenceWBPaper00006388
Curator_confirmedWBPerson2987
WBPhenotype:0001653Paper_evidenceWBPaper00006388
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00003022Paper_evidenceWBPaper00006388
Curator_confirmedWBPerson2987
WBPhenotype:0002226Paper_evidenceWBPaper00006388
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00003058Paper_evidenceWBPaper00006388
Curator_confirmedWBPerson2987
ReferenceWBPaper00006388
WBPaper00033166
WBPaper00048917
RemarkSuppresses an activated ras allele [050715 td3]Paper_evidenceWBPaper00006388
MethodSubstitution_allele