WormBase Tree Display for Variation: WBVar00088322
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| WBVar00088322 | Evidence | Paper_evidence | WBPaper00002150 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Name | Public_name | ku114 | |||||||
| Other_name | Y54E10BL.6.1:c.711C>T | ||||||||
| CE25437:p.Pro237= | |||||||||
| HGVSg | CHROMOSOME_I:g.3007931G>A | ||||||||
| Sequence_details | SMap | S_parent | Sequence | Y54E10BL | |||||
| Flanking_sequences | atttatcttttaaaaaattcaaatttcagcc | gaacgactcacaggatcccactatacaatt | |||||||
| Mapping_target | Y54E10BL | ||||||||
| Type_of_mutation | Substitution | c | t | Paper_evidence | WBPaper00002150 | ||||
| SeqStatus | Sequenced | ||||||||
| Variation_type | Allele | ||||||||
| Origin | Species | Caenorhabditis elegans | |||||||
| Strain | WBStrain00026500 | ||||||||
| WBStrain00030715 | |||||||||
| WBStrain00030722 | |||||||||
| Laboratory | MH | ||||||||
| Status | Live | ||||||||
| Affects | Gene | WBGene00003186 | |||||||
| Transcript | Y54E10BL.6.1 | VEP_consequence | splice_region_variant,synonymous_variant | ||||||
| VEP_impact | LOW | ||||||||
| HGVSc | Y54E10BL.6.1:c.711C>T | ||||||||
| HGVSp | CE25437:p.Pro237= | ||||||||
| cDNA_position | 714 | ||||||||
| CDS_position | 711 | ||||||||
| Protein_position | 237 | ||||||||
| Exon_number | 7/9 | ||||||||
| Codon_change | ccC/ccT | ||||||||
| Amino_acid_change | P | ||||||||
| Interactor | WBInteraction000519075 | ||||||||
| WBInteraction000524417 | |||||||||
| Genetics | Interpolated_map_position | I | -5.23812 | ||||||
| Description | Phenotype | WBPhenotype:0001645 | Paper_evidence | WBPaper00005245 | |||||
| WBPaper00006119 | |||||||||
| WBPaper00029116 | |||||||||
| Curator_confirmed | WBPerson1754 | ||||||||
| Remark | Mutation blocks muscle protein degradation increase in let-60(ga89) animals | Paper_evidence | WBPaper00005245 | ||||||
| Curator_confirmed | WBPerson1754 | ||||||||
| Blocks muscle protein degradation induced by clr-1(e1745) | Paper_evidence | WBPaper00006119 | |||||||
| Curator_confirmed | WBPerson1754 | ||||||||
| Blocks protein degradation in response to treatment with the AGE-1 inhibitor LY-294002 | Paper_evidence | WBPaper00029116 | |||||||
| Curator_confirmed | WBPerson1754 | ||||||||
| Affected_by | Molecule | WBMol:00005384 | Paper_evidence | WBPaper00029116 | |||||
| Curator_confirmed | WBPerson1754 | ||||||||
| Phenotype_assay | Genotype | let-60(ga89) | Paper_evidence | WBPaper00005245 | |||||
| Curator_confirmed | WBPerson1754 | ||||||||
| clr-1(e1745) | Paper_evidence | WBPaper00006119 | |||||||
| Curator_confirmed | WBPerson1754 | ||||||||
| Phenotype_not_observed | WBPhenotype:0000062 | Person_evidence | WBPerson261 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | viable | Person_evidence | WBPerson261 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0001060 | Paper_evidence | WBPaper00003955 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Affected_by | Molecule | WBMol:00001063 | Paper_evidence | WBPaper00003955 | |||||
| Curator_confirmed | WBPerson712 | ||||||||
| EQ_annotations | Anatomy_term | WBbt:0005672 | PATO:0000460 | Paper_evidence | WBPaper00003955 | ||||
| Curator_confirmed | WBPerson712 | ||||||||
| Reference | WBPaper00029116 | ||||||||
| WBPaper00015792 | |||||||||
| WBPaper00006119 | |||||||||
| WBPaper00015779 | |||||||||
| WBPaper00005245 | |||||||||
| WBPaper00003955 | |||||||||
| WBPaper00015066 | |||||||||
| WBPaper00022141 | |||||||||
| WBPaper00025469 | |||||||||
| Method | Substitution_allele |
