WormBase Tree Display for Variation: WBVar00088232
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| WBVar00088232 | Name | Public_name | k530 | |||||
|---|---|---|---|---|---|---|---|---|
| Sequence_details | Type_of_mutation | Insertion | ||||||
| SeqStatus | Pending_curation | |||||||
| Variation_type | Allele | |||||||
| Transposon_insertion | Tc1 | |||||||
| Origin | Species | Caenorhabditis elegans | ||||||
| Strain | WBStrain00026560 | |||||||
| Laboratory | MJ | |||||||
| Status | Live | |||||||
| Affects | Gene | WBGene00006599 | ||||||
| Interactor | WBInteraction000503972 | |||||||
| WBInteraction000536529 | ||||||||
| WBInteraction000536533 | ||||||||
| Description | Phenotype | WBPhenotype:0001221 | Paper_evidence | WBPaper00037875 | ||||
| Curator_confirmed | WBPerson242 | |||||||
| WBPhenotype:0001278 | Paper_evidence | WBPaper00041022 | ||||||
| Curator_confirmed | WBPerson2987 | |||||||
| Remark | tpa-1(k530) abolished the induction of Pnlp-29::GFP expression induced by Pcol-19::GPA-12* (* activated form of GPA-12) | Paper_evidence | WBPaper00041022 | |||||
| Curator_confirmed | WBPerson2987 | |||||||
| Phenotype_assay | Genotype | Pnlp-29::GFP; Pcol-19::GPA-12* (* activated form of GPA-12) | Paper_evidence | WBPaper00041022 | ||||
| Curator_confirmed | WBPerson2987 | |||||||
| WBPhenotype:0001400 | Paper_evidence | WBPaper00027200 | ||||||
| Curator_confirmed | WBPerson712 | |||||||
| Remark | Pharyngeal MPK-1 (p-MPK-1::GFP) activation was greatly reduced compared induction in wild-type worms at 3 days of starvation as assayed by Western blot. | Paper_evidence | WBPaper00027200 | |||||
| Curator_confirmed | WBPerson712 | |||||||
| Phenotype_assay | Temperature | 20 | Paper_evidence | WBPaper00027200 | ||||
| Curator_confirmed | WBPerson712 | |||||||
| Genotype | adIs2038[myo-2p::mpk-1K57R::GFP] | Paper_evidence | WBPaper00027200 | |||||
| Curator_confirmed | WBPerson712 | |||||||
| WBPhenotype:0001800 | Paper_evidence | WBPaper00033094 | ||||||
| Curator_confirmed | WBPerson2021 | |||||||
| Remark | Mutants showed almost complete abrogation of pnlp-29::GFP expression in all epidermal cells following infection with the fungus D. coniospora | Paper_evidence | WBPaper00033094 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Variation_effect | Null | Paper_evidence | WBPaper00033094 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Phenotype_assay | Genotype | frIs7 [pnlp-29::GFP] | Paper_evidence | WBPaper00033094 | ||||
| Curator_confirmed | WBPerson2021 | |||||||
| WBPhenotype:0001838 | Paper_evidence | WBPaper00033094 | ||||||
| Curator_confirmed | WBPerson2021 | |||||||
| Remark | PMA-induced reporter gene expression was abrogated in all the tpa-1 mutants, unlike wild-type | Paper_evidence | WBPaper00033094 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Variation_effect | Null | Paper_evidence | WBPaper00033094 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Phenotype_assay | Genotype | frIs7 [pnlp-29::GFP] | Paper_evidence | WBPaper00033094 | ||||
| Curator_confirmed | WBPerson2021 | |||||||
| WBPhenotype:0001839 | Paper_evidence | WBPaper00033094 | ||||||
| Curator_confirmed | WBPerson2021 | |||||||
| Remark | tpa-1mutants were resistant to the growth-inhibitory effects of 1 mg/ml PMA | Paper_evidence | WBPaper00033094 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Variation_effect | Null | Paper_evidence | WBPaper00033094 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Phenotype_assay | Genotype | frIs7 [pnlp-29::GFP] | Paper_evidence | WBPaper00033094 | ||||
| Curator_confirmed | WBPerson2021 | |||||||
| WBPhenotype:0001840 | Paper_evidence | WBPaper00033094 | ||||||
| Curator_confirmed | WBPerson2021 | |||||||
| Remark | Mutants were deficient in their response to injury | Paper_evidence | WBPaper00033094 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Variation_effect | Null | Paper_evidence | WBPaper00033094 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Phenotype_assay | Genotype | frIs7 [pnlp-29::GFP] | Paper_evidence | WBPaper00033094 | ||||
| Curator_confirmed | WBPerson2021 | |||||||
| Phenotype_not_observed | WBPhenotype:0000876 | Paper_evidence | WBPaper00033094 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Remark | Upon exposure to high salt, the response in all the tpa-1 mutants tested was close to that seen in wild-type worms | Paper_evidence | WBPaper00033094 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Variation_effect | Null | Paper_evidence | WBPaper00033094 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Phenotype_assay | Genotype | frIs7 [pnlp-29::GFP] | Paper_evidence | WBPaper00033094 | ||||
| Curator_confirmed | WBPerson2021 | |||||||
| Reference | WBPaper00041022 | |||||||
| WBPaper00033094 | ||||||||
| WBPaper00027200 | ||||||||
| WBPaper00037875 | ||||||||
| Method | Transposon_insertion |
