WormBase Tree Display for Variation: WBVar00087778

WBVar00087778 Name: Public_name: hc77
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00000394
    Laboratory: BA
    Status: Live
  Affects: Gene: WBGene00004965
  Description: Phenotype: WBPhenotype:0000037 Paper_evidence: WBPaper00001075
        Curator_confirmed: WBPerson2021
        Remark: hc77 hermaphrodites produce a number of round thinly shelled eggs (as opposed to wild-type oblong eggs) Paper_evidence: WBPaper00001075
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001075
          Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00001075
            Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25C Paper_evidence: WBPaper00001075
              Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 25C Paper_evidence: WBPaper00001075
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000351 Paper_evidence: WBPaper00001075
        Curator_confirmed: WBPerson2021
        Remark: Thinly shelled eggs produced by hc77 hermaphrodites do not hatch Paper_evidence: WBPaper00001075
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001075
          Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00001075
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00001075
                Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25C Paper_evidence: WBPaper00001075
              Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 25C Paper_evidence: WBPaper00001075
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000357 Paper_evidence: WBPaper00001075
        Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001075
          Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00001075
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001075
                Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25C Paper_evidence: WBPaper00001075
              Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 16C, 25C Paper_evidence: WBPaper00001075
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000693 Paper_evidence: WBPaper00001075
        Curator_confirmed: WBPerson2021
        Remark: At 25C, males fail to sire progeny in mating experiments Paper_evidence: WBPaper00001075
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001075
          Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00001075
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000056 PATO:0000460 Paper_evidence: WBPaper00001075
                Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25C Paper_evidence: WBPaper00001075
              Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 25C Paper_evidence: WBPaper00001075
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000749 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: hermaphrodites and males grown at 25C produce motile sperm that fertilize oocytes leading to abnormal early development, defective. Similar phenotype in hc77/Df. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
        Ease_of_scoring: ES2_Difficult_to_score: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0001360 Paper_evidence: WBPaper00001075
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson2021
          WBPerson712
        Remark: Self-fertility 3% (25C) 100% (16C). Similar phenotype in hc77/Df. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00001075
          Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00001075
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001075
                Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25C Paper_evidence: WBPaper00001075
              Curator_confirmed: WBPerson2021
            25 Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
        Phenotype_assay: Temperature: 16C, 25C Paper_evidence: WBPaper00001075
              Curator_confirmed: WBPerson2021
    Phenotype_not_observed: WBPhenotype:0000390 Paper_evidence: WBPaper00001075
        Curator_confirmed: WBPerson2021
        Remark: Adults produce large numbers of spermatids that activate in vitro after pronase treatment to form spermatozoa that are cytologically indistinguishable from wild type Paper_evidence: WBPaper00001075
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001075
          Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00001075
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00001075
                Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25C Paper_evidence: WBPaper00001075
              Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 16C, 25C Paper_evidence: WBPaper00001075
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000736 Paper_evidence: WBPaper00040312
        Curator_confirmed: WBPerson712
        Remark: GFP-LGG-1-positive autophagosomes were induced around the paternal pronuclear DNA. In polyspermic embryos, autophagosomes were induced around each paternal pronuclear DNA. Paper_evidence: WBPaper00040312
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: Paper_evidence: WBPaper00040312
              Curator_confirmed: WBPerson712
      WBPhenotype:0001135 Paper_evidence: WBPaper00040312
        Curator_confirmed: WBPerson712
        Remark: Paternal mitochondria did not persist. Paper_evidence: WBPaper00040312
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: Paper_evidence: WBPaper00040312
              Curator_confirmed: WBPerson712
      WBPhenotype:0001375 Paper_evidence: WBPaper00040312
        Curator_confirmed: WBPerson712
        Remark: GFP-LGG-1-positive autophagosomes were induced around the paternal pronuclear DNA. Paper_evidence: WBPaper00040312
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: Paper_evidence: WBPaper00040312
              Curator_confirmed: WBPerson712
  Reference: WBPaper00040312
    WBPaper00001075
    WBPaper00013873
    WBPaper00011376
  Method: Allele