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WormBase Tree Display for Variation: WBVar00087750

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Name Class

WBVar00087750NamePublic_namehc17
Other_namehc17ts
Sequence_detailsSeqStatusPending_curation
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
Strain (11)
Component_of_genotypeWBGenotype00000033
LaboratoryBA
CF
StatusLive
AffectsGeneWBGene00001411
Interactor (11)
GeneticsMapping_dataIn_multi_point114
DescriptionPhenotypeWBPhenotype:0000113Paper_evidenceWBPaper00031903
Curator_confirmedWBPerson712
RemarkExpression of 21 U RNAs was reduced although expression of miRNA let-7 was unaffected.Paper_evidenceWBPaper00031903
Curator_confirmedWBPerson712
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00031903
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000038PATO:0000460Paper_evidenceWBPaper00031903
Curator_confirmedWBPerson712
Phenotype_assayTreatmentSamples were enriched for RNAs <200 bp and used in northern analysis to examine the expression profile of the 21U-RNA 21ur-1 asPaper_evidenceWBPaper00031903
Curator_confirmedWBPerson712
WBPhenotype:0000114Paper_evidenceWBPaper00039871
Curator_confirmedWBPerson712
Remarkvit-2 and vit-5 mRNA were significantly reduced on adult days 1 and 2 compared to wildtype, whereas the levels of sod-3 mRNA were roughly normal. Levels of vit-2 mRNA were elevated in mated hermaphrodites in contrast to unmated hermaphrodites, whereas mating had no effect on sod-3 mRNA.Paper_evidenceWBPaper00039871
Curator_confirmedWBPerson712
WBPhenotype:0000136Paper_evidenceWBPaper00031962
Curator_confirmedWBPerson712
RemarkLevels of prg-1 mRNA were almost 2-fold greater than in wild-type animals as assayed by qRT-PCR.Paper_evidenceWBPaper00031962
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00031962
Curator_confirmedWBPerson712
Phenotype_assayTemperature25Paper_evidenceWBPaper00031962
Curator_confirmedWBPerson712
WBPhenotype:0000137Paper_evidenceWBPaper00034714
Curator_confirmedWBPerson2021
Remarkelt-1 was not detectably expressed in the germ line of fem-1 adultsPaper_evidenceWBPaper00034714
Curator_confirmedWBPerson2021
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00034714
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00034714
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentIn situ hybridization with elt-1 antisense probePaper_evidenceWBPaper00034714
Curator_confirmedWBPerson2021
WBPhenotype:0000290Paper_evidenceWBPaper00031961
Curator_confirmedWBPerson712
WBPhenotype:0000670Paper_evidenceWBPaper00031962
Curator_confirmedWBPerson712
RemarkAnimals were devoid of sperm.Paper_evidenceWBPaper00031962
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00031962
Curator_confirmedWBPerson712
Phenotype_assayTemperature25Paper_evidenceWBPaper00031962
Curator_confirmedWBPerson712
WBPhenotype:0000687Paper_evidenceWBPaper00000724
Person_evidenceWBPerson261
Curator_confirmedWBPerson2021
WBPerson712
Remarkhc17 is a weaker fem-1 mutation. The feminization phenotype is restricted to the gonads of XX and XO animals.Paper_evidenceWBPaper00000724
Curator_confirmedWBPerson2021
causes only partial XO feminization at 25C, XX self fertile at 20CPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
PenetranceIncompletePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00000724
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000041PATO:0000460Paper_evidenceWBPaper00000724
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00000724
Curator_confirmedWBPerson2021
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000688Paper_evidenceWBPaper00031903
WBPaper00032067
Curator_confirmedWBPerson712
PenetranceCompletePaper_evidenceWBPaper00031903
Curator_confirmedWBPerson712
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00031903
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00031903
Curator_confirmedWBPerson712
Phenotype_assayTemperature25Paper_evidenceWBPaper00031903
Curator_confirmedWBPerson712
WBPhenotype:0001410Paper_evidenceWBPaper00040337
Curator_confirmedWBPerson712
RemarkAntibodies that recognize the nearly identical GSP-3 and GSP-4 (GSP-3/4) proteins were used to show that, similar to the sperm-specific MSP protein, GSP-3/4 are expressed only in sperm-producing fem-3(q20gf) but not oocyte-producing fem-1(hc17lf) mutant hermaphrodites.Paper_evidenceWBPaper00040337
Curator_confirmedWBPerson712
WBPhenotype:0001759Paper_evidenceWBPaper00031961
Curator_confirmedWBPerson712
Remark21U-RNA-1 and 21U-RNA-3442 RNAs were greatly reduced from RNA preparations from populations at 25C. Whereas, 21U-RNAs were expressed at approximately equal levels in male or female-enriched populations of wild-type animals.Paper_evidenceWBPaper00031961
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000039Paper_evidenceWBPaper00032067
Curator_confirmedWBPerson712
RemarkAnimals exhibited life span characteristics similar to wild-type.Paper_evidenceWBPaper00032067
Curator_confirmedWBPerson712
WBPhenotype:0000394Paper_evidenceWBPaper00031961
Curator_confirmedWBPerson712
RemarkPLG-1 was detectable in Western blots of protein lysates.Paper_evidenceWBPaper00031961
Curator_confirmedWBPerson712
WBPhenotype:0000416Paper_evidenceWBPaper00039871
Curator_confirmedWBPerson712
RemarkYolk protein levels were normal to slightly elevated in unmated animals.Paper_evidenceWBPaper00039871
Curator_confirmedWBPerson712
WBPhenotype:0001740Paper_evidenceWBPaper00032067
Curator_confirmedWBPerson712
RemarkBased on an aging model built on pharynx images from adults days 0-12. In this study fem-1(hc17) was the control.Paper_evidenceWBPaper00032067
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0003681PATO:0000460Paper_evidenceWBPaper00032067
Curator_confirmedWBPerson712
Life_stageWBls:0000041PATO:0000460Paper_evidenceWBPaper00032067
Curator_confirmedWBPerson712
Phenotype_assayTemperature25Paper_evidenceWBPaper00032067
Curator_confirmedWBPerson712
WBPhenotype:0001759Paper_evidenceWBPaper00031962
Curator_confirmedWBPerson712
Remark21UR-1 levels were unchanged at the restrictive temperature compared to control animals.Paper_evidenceWBPaper00031962
Curator_confirmedWBPerson712
EQ_annotationsGO_termGO:0034585PATO:0000460Paper_evidenceWBPaper00031962
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00031962
Curator_confirmedWBPerson712
Phenotype_assayTemperature25Paper_evidenceWBPaper00031962
Curator_confirmedWBPerson712
WBPhenotype:0001779Paper_evidenceWBPaper00035664
Curator_confirmedWBPerson2021
RemarkExpression of miRNAs 35-41 is unaffectedPaper_evidenceWBPaper00035664
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00035664
Curator_confirmedWBPerson2021
Reference (25)
MethodAllele