WormBase Tree Display for Variation: WBVar00053967

WBVar00053967 Evidence: Paper_evidence: WBPaper00024985
  Name: Public_name: ce81
    Other_name: R06A10.2b.1:c.274C>T
      R06A10.2a.1:c.553C>T
      CE49189:p.Arg92Cys
      CE47896:p.Arg185Cys
    HGVSg: CHROMOSOME_I:g.1071691C>T
  Sequence_details: SMap: S_parent: Sequence: R06A10
    Flanking_sequences: gatccatccgagcaggacatccttcggtgt gtgtcatgacaaccggcattttcgagacca
    Mapping_target: R06A10
    Type_of_mutation: Substitution: c t Paper_evidence: WBPaper00024985
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00023478
    Laboratory: KG
    Status: Live
  Affects: Gene: WBGene00001745
    Transcript: R06A10.2a.1 (12)
      R06A10.2b.1 (12)
    Interactor: WBInteraction000518053
      WBInteraction000518360
      WBInteraction000518361
  Genetics: Interpolated_map_position: I -16.9675
  Description: Phenotype: WBPhenotype:0000016 Paper_evidence: WBPaper00038528
        Curator_confirmed: WBPerson712
        Variation_effect: Hypermorph_gain_of_function: Paper_evidence: WBPaper00038528
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00003650 Paper_evidence: WBPaper00038528
              Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0007833 PATO:0001549 Paper_evidence: WBPaper00038528
                Curator_confirmed: WBPerson712
      WBPhenotype:0000105 Paper_evidence: WBPaper00027739
        Curator_confirmed: WBPerson2021
        Remark: Oocytes in mutant females exhibit increased meiotic maturation rates in the absence of sperm Paper_evidence: WBPaper00027739
            Curator_confirmed: WBPerson2021
        Variation_effect: Hypermorph_gain_of_function: Paper_evidence: WBPaper00027739
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0006797 PATO:0000460 Paper_evidence: WBPaper00027739
                Curator_confirmed: WBPerson2021
          Life_stage: WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00027739
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: fog-3(q443) Paper_evidence: WBPaper00027739
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000106 Paper_evidence: WBPaper00027739
        Curator_confirmed: WBPerson2021
        Remark: Mutant hermaphrodites exhibit an expanded pattern of MAPK activation in which MAPKYT staining extends to distal oocytes Paper_evidence: WBPaper00027739
            Curator_confirmed: WBPerson2021
        Variation_effect: Hypermorph_gain_of_function: Paper_evidence: WBPaper00027739
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0006797 PATO:0000460 Paper_evidence: WBPaper00027739
                Curator_confirmed: WBPerson2021
          Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00027739
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: Antibody staining to the diphosphorylated activated form of MAPK (MAPK-YT) Paper_evidence: WBPaper00027739
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000420 Paper_evidence: WBPaper00038528
        Curator_confirmed: WBPerson712
      WBPhenotype:0000642 Paper_evidence: WBPaper00038528
        Curator_confirmed: WBPerson712
        Variation_effect: Hypermorph_gain_of_function: Paper_evidence: WBPaper00038528
            Curator_confirmed: WBPerson712
      WBPhenotype:0001524 Paper_evidence: WBPaper00045634
        Curator_confirmed: WBPerson13849
        Remark: decreased total quiescence Paper_evidence: WBPaper00045634
            Curator_confirmed: WBPerson13849
  Reference: WBPaper00038528
    WBPaper00027739
    WBPaper00024985
    WBPaper00045634
  Method: Substitution_allele