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WormBase Tree Display for Variation: WBVar00000230

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Name Class

WBVar00000230EvidencePaper_evidenceWBPaper00005695
NamePublic_namear202
Other_nameCE00237:p.Gly529Glu
F02A9.6.1:c.1586G>A
HGVSgCHROMOSOME_III:g.9096522G>A
Sequence_detailsSMapS_parentSequenceF02A9
Flanking_sequencesgtaattttgatggaggtgattgctcaggaggcaaagaccattctccaaatgtcaataccc
Mapping_targetF02A9
Type_of_mutationSubstitutionga
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
Strain (12)
LaboratoryGS
JK
StatusLive
AffectsGeneWBGene00001609
TranscriptF02A9.6.1 (12)
Interactor (40)
GeneticsInterpolated_map_positionIII0.163806
DescriptionPhenotypeWBPhenotype:0000038Paper_evidenceWBPaper00050044
Curator_confirmedWBPerson17144
RemarkIncrease rupture post-reproductivelyPaper_evidenceWBPaper00050044
Curator_confirmedWBPerson17144
WBPhenotype:0000050Paper_evidenceWBPaper00040544
Curator_confirmedWBPerson712
Remarktemperature-sensitive mutation that causes embryonic lethality at its restrictive temperaturePaper_evidenceWBPaper00040544
Curator_confirmedWBPerson712
temperature-sensitive hyperactive mutation that causes embryonic lethality at its restrictive temperaturePaper_evidenceWBPaper00040544
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00040544
Curator_confirmedWBPerson712
WBPhenotype:0000315Paper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
RemarkAnimals had a higher arousal threshold to mechanosensory stimuli than control animals; animals responded less frequently to stimuli than control quiescent animals.Paper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
Variation_effectGain_of_function_undetermined_typePaper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
WBPhenotype:0000688Paper_evidenceWBPaper00040544
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00040544
Curator_confirmedWBPerson712
WBPhenotype:0000823Paper_evidenceWBPaper00032182
Curator_confirmedWBPerson712
RemarkAnimals displayed germ cell over-proliferation.Paper_evidenceWBPaper00032182
Curator_confirmedWBPerson712
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00032182
Curator_confirmedWBPerson712
WBPhenotype:0001038Paper_evidenceWBPaper00032182
WBPaper00034675
Curator_confirmedWBPerson712
WBPerson2987
PenetranceHigh90-99%Paper_evidenceWBPaper00034675
Curator_confirmedWBPerson2987
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00032182
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00034675
Curator_confirmedWBPerson2987
Phenotype_assayTemperature25CPaper_evidenceWBPaper00034675
Curator_confirmedWBPerson2987
Genotypeglp-1(ar202) IIIPaper_evidenceWBPaper00034675
Curator_confirmedWBPerson2987
WBPhenotype:0001184Paper_evidenceWBPaper00032310
Curator_confirmedWBPerson2987
Remarkglp-1(ar202gf) mutants with a hyperactive GLP-1 showed a factor of 1.7 fat increase (Figure 2H,I,K)Paper_evidenceWBPaper00032310
Curator_confirmedWBPerson2987
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00032310
Curator_confirmedWBPerson2987
WBPhenotype:0001408Paper_evidenceWBPaper00034719
Curator_confirmedWBPerson2021
RemarkThere is also an increase in distal METT-10 levels when the glp-1(ar202) gain-of-function mutant is shifted to 25C to induce tumorsPaper_evidenceWBPaper00034719
Curator_confirmedWBPerson2021
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00034719
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitive25CPaper_evidenceWBPaper00034719
Curator_confirmedWBPerson2021
WBPhenotype:0001524Paper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
RemarkAnimals exhibited increased L4/A quiescence compared to control animals.Paper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
Variation_effectGain_of_function_undetermined_typePaper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000136Paper_evidenceWBPaper00031962
Curator_confirmedWBPerson712
RemarkLevels of prg-1 mRNA were similar to that measured in wild-type animals, as assayed by qRT-PCR.Paper_evidenceWBPaper00031962
Curator_confirmedWBPerson712
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00031962
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00031962
Curator_confirmedWBPerson712
Phenotype_assayTemperature25Paper_evidenceWBPaper00031962
Curator_confirmedWBPerson712
WBPhenotype:0000412Paper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
RemarkAnimals responded to octanol like control animals, regardless of temperature.Paper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
Variation_effectGain_of_function_undetermined_typePaper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00001966Paper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
WBPhenotype:0000641Paper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
RemarkAnimals did not exhibit a significant difference in basal locomotion activity compared to control animals.Paper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
Variation_effectGain_of_function_undetermined_typePaper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
WBPhenotype:0001759Paper_evidenceWBPaper00031962
Curator_confirmedWBPerson712
Remark21UR-1 levels were unchanged in glp-1(ar202gf,ts) mutants at the restrictive temperature compared to control animals.Paper_evidenceWBPaper00031962
Curator_confirmedWBPerson712
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00031962
Curator_confirmedWBPerson712
EQ_annotationsGO_termGO:0034585PATO:0000460Paper_evidenceWBPaper00031962
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00031962
Curator_confirmedWBPerson712
Phenotype_assayTemperature25Paper_evidenceWBPaper00031962
Curator_confirmedWBPerson712
Reference (15)
RemarkG529E,extracellular domain
MethodSubstitution_allele