WormBase Tree Display for Variation: WBVar00000195

WBVar00000195 Name: Public_name: ar105
    Other_name: F29G9.4b.1:c.355C>T
      F29G9.4a.3:c.-54C>T
      F29G9.4a.1:c.-54C>T
      F29G9.4a.5:c.-54C>T
      F29G9.4a.4:c.-54C>T
      CE39151:p.Gln119Ter
      F29G9.4a.2:c.-54C>T
    HGVSg: CHROMOSOME_V:g.6011242C>T
  Sequence_details: SMap: S_parent: Sequence: F29G9
    Flanking_sequences: tcaggtccgatcccagcaatcccgactaat aaatctacaatcgaacattcaccgatttct
    Mapping_target: F29G9
    Type_of_mutation: Substitution: c t Paper_evidence: WBPaper00026611
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00008001
    Laboratory: GS
    Status: Live
  Affects: Gene: WBGene00001345
    Transcript: F29G9.4b.1 VEP_consequence: stop_gained
        VEP_impact: HIGH
        HGVSc: F29G9.4b.1:c.355C>T
        HGVSp: CE39151:p.Gln119Ter
        cDNA_position: 355
        CDS_position: 355
        Protein_position: 119
        Exon_number: 3/7
        Codon_change: Caa/Taa
        Amino_acid_change: Q/*
      F29G9.4a.1 VEP_consequence: 5_prime_UTR_variant
        VEP_impact: MODIFIER
        HGVSc: F29G9.4a.1:c.-54C>T
        cDNA_position: 167
        Exon_number: 3/9
      F29G9.4a.3 VEP_consequence: 5_prime_UTR_variant
        VEP_impact: MODIFIER
        HGVSc: F29G9.4a.3:c.-54C>T
        cDNA_position: 2135
        Exon_number: 2/8
      F29G9.4a.5 VEP_consequence: 5_prime_UTR_variant
        VEP_impact: MODIFIER
        HGVSc: F29G9.4a.5:c.-54C>T
        cDNA_position: 32
        Exon_number: 1/7
      F29G9.4a.2 VEP_consequence: 5_prime_UTR_variant
        VEP_impact: MODIFIER
        HGVSc: F29G9.4a.2:c.-54C>T
        cDNA_position: 853
        Exon_number: 3/9
      F29G9.4a.4 VEP_consequence: 5_prime_UTR_variant
        VEP_impact: MODIFIER
        HGVSc: F29G9.4a.4:c.-54C>T
        cDNA_position: 277
        Exon_number: 3/9
    Interactor: WBInteraction000051961
      WBInteraction000502145
      WBInteraction000502146
      WBInteraction000502147
      WBInteraction000502906
      WBInteraction000502933
      WBInteraction000503371
      WBInteraction000503372
      WBInteraction000541740
  Genetics: Interpolated_map_position: V -0.460696
  Description: Phenotype: WBPhenotype:0000289 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: abnormal uterus Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000510 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: abnormal L4 vulval invagination Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000665 Paper_evidence: WBPaper00033081
        Curator_confirmed: WBPerson2021
        Remark: No proper connection between vulF and the uterus Paper_evidence: WBPaper00033081
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000688 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
      WBPhenotype:0000695 Paper_evidence: WBPaper00033081
        Curator_confirmed: WBPerson2021
        Remark: The mid-L4 vulval morphology of fos-1(ar105) mutants is abnormal. vulF is clearly misshapen Paper_evidence: WBPaper00033081
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000696 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
      WBPhenotype:0001260 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: abnormal oocytes Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0001652 Paper_evidence: WBPaper00039950
        Curator_confirmed: WBPerson712
        Remark: 100% no invasion. Paper_evidence: WBPaper00039950
            Curator_confirmed: WBPerson712
      WBPhenotype:0002280 Paper_evidence: WBPaper00046151
        Curator_confirmed: WBPerson557
        Remark: daf-2(e1370) animals survive much better than WT when grown on 400 mmol/L NaCl. Paper_evidence: WBPaper00046151
            Curator_confirmed: WBPerson557
        Phenotype_assay: Treatment: Animals grown on 400 mmol/L NaCl. Paper_evidence: WBPaper00046151
              Curator_confirmed: WBPerson557
    Phenotype_not_observed: WBPhenotype:0000104 Paper_evidence: WBPaper00033081
        Curator_confirmed: WBPerson2021
        Remark: Polarity is normal in all mutants Paper_evidence: WBPaper00033081
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: kuIs47 [AJM-1::GFP] Paper_evidence: WBPaper00033081
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000220 Paper_evidence: WBPaper00033081
        Curator_confirmed: WBPerson2021
        Remark: zmp-1 and lin-3 markers are expressed in the correct cell at the expected time in all mutants Paper_evidence: WBPaper00033081
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: syIs107[lin-3(delta-pes-10)::GFP], syIs49[zmp- 1::GFP] Paper_evidence: WBPaper00033081
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000679 Paper_evidence: WBPaper00032446
        Curator_confirmed: WBPerson2021
        Remark: MIG-2::GFP, marking the invasive membrane, was localized normally in fos-1a mutants Paper_evidence: WBPaper00032446
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: muIs27[GFP::mig-2] Paper_evidence: WBPaper00032446
              Curator_confirmed: WBPerson2021
  Reference: WBPaper00039950
    WBPaper00032446
    WBPaper00025842
    WBPaper00033081
    WBPaper00046151
  Method: Substitution_allele