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WormBase Tree Display for Variation: WBVar00000115

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Name Class

WBVar00000115EvidencePaper_evidenceWBPaper00005350
NamePublic_nameak47
Other_nameT09A12.3a.1:c.1188+21_2223+127del
HGVSgCHROMOSOME_IV:g.8214802_8216761del
Sequence_detailsSMapS_parentSequenceT09A12
Flanking_sequencestaacattaatctgagctggcaacaacgattccagtaaaatcgccgcttaccccataaacc
Mapping_targetT09A12
Type_of_mutationDeletion
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00005264
WBStrain00007483
WBStrain00026384
WBStrain00026394
WBStrain00026395
WBStrain00040166
LaboratoryVM
StatusLive
AffectsGeneWBGene00003839
TranscriptT09A12.3a.1VEP_consequencesplice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
VEP_impactHIGH
HGVScT09A12.3a.1:c.1188+21_2223+127del
Intron_number5-11/14
Exon_number6-11/15
T09A12.3b.1VEP_consequencesplice_acceptor_variant,splice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
VEP_impactHIGH
Intron_number1-5/7
Exon_number1-5/8
Interactor (24)
GeneticsInterpolated_map_positionIV3.68001
Mapping_dataIn_multi_point4555
DescriptionPhenotypeWBPhenotype:0000061Paper_evidenceWBPaper00045595
Curator_confirmedWBPerson557
RemarkAuthors report a modest increase in longevity in ocr-2(ak47) animals.Paper_evidenceWBPaper00045595
Curator_confirmedWBPerson557
WBPhenotype:0000303Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00002819Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005670PATO:0000460Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
WBPhenotype:0000412Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
RemarkAnimals exhibited a minimal but significant defect in their response behavior to exposure to 100% octanol.Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00001966Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005665PATO:0000460Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
WBbt:0005661PATO:0000460Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
WBbt:0005671PATO:0000460Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
WBPhenotype:0000480Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00005360Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005670PATO:0000460Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
WBPhenotype:0000523Paper_evidenceWBPaper00059946
Curator_confirmedWBPerson712
RemarkIn response to SDS only a partial avoidance defect was seen for osm-9 and ocr-2 single mutants at 0.1%-0.001%Paper_evidenceWBPaper00059946
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003977Paper_evidenceWBPaper00059946
Curator_confirmedWBPerson712
WBPhenotype:0000592Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00002862Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005665PATO:0000460Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
WBPhenotype:0000671Paper_evidenceWBPaper00059946
Curator_confirmedWBPerson712
RemarkIn response to copper (CuCl2), at each concentration the osm-9 and ocr-2 single mutants, as well as the osm-9 ocr-2 double mutant, were partially defective in the avoidance response (Figure 1B). Only at the lowest concentrations tested (0.5mM and 0.25mM) were either the single or double mutant animals essentially lacking response (Figure 1B).Paper_evidenceWBPaper00059946
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00002485Paper_evidenceWBPaper00059946
Curator_confirmedWBPerson712
WBPhenotype:0001450Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003977Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005665PATO:0000460Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
WBPhenotype:0002378Paper_evidenceWBPaper00058803
Curator_confirmedWBPerson36360
Phenotype_not_observedWBPhenotype:0000630Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003904Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005665PATO:0000460Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
WBPhenotype:0001273Paper_evidenceWBPaper00031874
WBPaper00038142
Curator_confirmedWBPerson2021
WBPerson712
RemarkThe levels of heat shock-dependent accumulation of hsp70 (C12C8.1) mRNA in ocr-2 mutants were comparable to wild-typePaper_evidenceWBPaper00031874
Curator_confirmedWBPerson2021
Using a thermal barrier assay to test heat avoidance, no defect in heat avoidance was observed.Paper_evidenceWBPaper00038142
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were exposed to a transient increase in temperature (30C or 34C for 15 min), and their heat shock response was measured as the total amount of hsp70 (C12C8.1) mRNA, 2 hours after heat shockPaper_evidenceWBPaper00031874
Curator_confirmedWBPerson2021
WBPhenotype:0001454Paper_evidenceWBPaper00059946
Curator_confirmedWBPerson712
RemarkIndividual loss of neither OSM-9 nor OCR-2 function affected response to 10mM quinine (Figure 1A), similar to our previous report (Ezak et al. 2010). Further, osm-9 and ocr-2 single mutants responded similarly to wild-type animals across the range of quinine concentrations tested (10mM - 1mM, Figure 1A).Paper_evidenceWBPaper00059946
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003904Paper_evidenceWBPaper00059946
Curator_confirmedWBPerson712
WBPhenotype:0001765Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
RemarkMutants respond normally to CO2Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
Phenotype_assayTreatment10% CO2Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
WBPhenotype:0001939Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003731Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
WBMol:00003904Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
WBMol:00003565Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
WBMol:00001530Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
WBMol:00005022Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
ReferenceWBPaper00038142
WBPaper00031936
WBPaper00031874
WBPaper00035961
WBPaper00025807
WBPaper00058803
WBPaper00059946
WBPaper00045595
WBPaper00064938
WBPaper00064927
MethodDeletion_allele