WormBase Tree Display for Variation: WBVar00000115
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WBVar00000115 | Evidence | Paper_evidence | WBPaper00005350 | ||||||
---|---|---|---|---|---|---|---|---|---|
Name | Public_name | ak47 | |||||||
Other_name | T09A12.3a.1:c.1188+21_2223+127del | ||||||||
HGVSg | CHROMOSOME_IV:g.8214802_8216761del | ||||||||
Sequence_details | SMap | S_parent | Sequence | T09A12 | |||||
Flanking_sequences | taacattaatctgagctggcaacaacgatt | ccagtaaaatcgccgcttaccccataaacc | |||||||
Mapping_target | T09A12 | ||||||||
Type_of_mutation | Deletion | ||||||||
SeqStatus | Sequenced | ||||||||
Variation_type | Allele | ||||||||
Origin | Species | Caenorhabditis elegans | |||||||
Strain | WBStrain00005264 | ||||||||
WBStrain00007483 | |||||||||
WBStrain00026384 | |||||||||
WBStrain00026394 | |||||||||
WBStrain00026395 | |||||||||
WBStrain00040166 | |||||||||
Laboratory | VM | ||||||||
Status | Live | ||||||||
Affects | Gene | WBGene00003839 | |||||||
Transcript | T09A12.3a.1 | VEP_consequence | splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant | ||||||
VEP_impact | HIGH | ||||||||
HGVSc | T09A12.3a.1:c.1188+21_2223+127del | ||||||||
Intron_number | 5-11/14 | ||||||||
Exon_number | 6-11/15 | ||||||||
T09A12.3b.1 | VEP_consequence | splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant | |||||||
VEP_impact | HIGH | ||||||||
Intron_number | 1-5/7 | ||||||||
Exon_number | 1-5/8 | ||||||||
Interactor (24) | |||||||||
Genetics | Interpolated_map_position | IV | 3.68001 | ||||||
Mapping_data | In_multi_point | 4555 | |||||||
Description | Phenotype | WBPhenotype:0000061 | Paper_evidence | WBPaper00045595 | |||||
Curator_confirmed | WBPerson557 | ||||||||
Remark | Authors report a modest increase in longevity in ocr-2(ak47) animals. | Paper_evidence | WBPaper00045595 | ||||||
Curator_confirmed | WBPerson557 | ||||||||
WBPhenotype:0000303 | Paper_evidence | WBPaper00035961 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Affected_by | Molecule | WBMol:00002819 | Paper_evidence | WBPaper00035961 | |||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0005670 | PATO:0000460 | Paper_evidence | WBPaper00035961 | ||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000412 | Paper_evidence | WBPaper00035961 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Animals exhibited a minimal but significant defect in their response behavior to exposure to 100% octanol. | Paper_evidence | WBPaper00035961 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Affected_by | Molecule | WBMol:00001966 | Paper_evidence | WBPaper00035961 | |||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0005665 | PATO:0000460 | Paper_evidence | WBPaper00035961 | ||||
Curator_confirmed | WBPerson712 | ||||||||
WBbt:0005661 | PATO:0000460 | Paper_evidence | WBPaper00035961 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBbt:0005671 | PATO:0000460 | Paper_evidence | WBPaper00035961 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000480 | Paper_evidence | WBPaper00035961 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Affected_by | Molecule | WBMol:00005360 | Paper_evidence | WBPaper00035961 | |||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0005670 | PATO:0000460 | Paper_evidence | WBPaper00035961 | ||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000523 | Paper_evidence | WBPaper00059946 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | In response to SDS only a partial avoidance defect was seen for osm-9 and ocr-2 single mutants at 0.1%-0.001% | Paper_evidence | WBPaper00059946 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Affected_by | Molecule | WBMol:00003977 | Paper_evidence | WBPaper00059946 | |||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000592 | Paper_evidence | WBPaper00035961 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Affected_by | Molecule | WBMol:00002862 | Paper_evidence | WBPaper00035961 | |||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0005665 | PATO:0000460 | Paper_evidence | WBPaper00035961 | ||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000671 | Paper_evidence | WBPaper00059946 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | In response to copper (CuCl2), at each concentration the osm-9 and ocr-2 single mutants, as well as the osm-9 ocr-2 double mutant, were partially defective in the avoidance response (Figure 1B). Only at the lowest concentrations tested (0.5mM and 0.25mM) were either the single or double mutant animals essentially lacking response (Figure 1B). | Paper_evidence | WBPaper00059946 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Affected_by | Molecule | WBMol:00002485 | Paper_evidence | WBPaper00059946 | |||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001450 | Paper_evidence | WBPaper00035961 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Affected_by | Molecule | WBMol:00003977 | Paper_evidence | WBPaper00035961 | |||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0005665 | PATO:0000460 | Paper_evidence | WBPaper00035961 | ||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0002378 | Paper_evidence | WBPaper00058803 | |||||||
Curator_confirmed | WBPerson36360 | ||||||||
Phenotype_not_observed | WBPhenotype:0000630 | Paper_evidence | WBPaper00035961 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Affected_by | Molecule | WBMol:00003904 | Paper_evidence | WBPaper00035961 | |||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0005665 | PATO:0000460 | Paper_evidence | WBPaper00035961 | ||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001273 | Paper_evidence | WBPaper00031874 | |||||||
WBPaper00038142 | |||||||||
Curator_confirmed | WBPerson2021 | ||||||||
WBPerson712 | |||||||||
Remark | The levels of heat shock-dependent accumulation of hsp70 (C12C8.1) mRNA in ocr-2 mutants were comparable to wild-type | Paper_evidence | WBPaper00031874 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
Using a thermal barrier assay to test heat avoidance, no defect in heat avoidance was observed. | Paper_evidence | WBPaper00038142 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_assay | Treatment | Animals were exposed to a transient increase in temperature (30C or 34C for 15 min), and their heat shock response was measured as the total amount of hsp70 (C12C8.1) mRNA, 2 hours after heat shock | Paper_evidence | WBPaper00031874 | |||||
Curator_confirmed | WBPerson2021 | ||||||||
WBPhenotype:0001454 | Paper_evidence | WBPaper00059946 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Individual loss of neither OSM-9 nor OCR-2 function affected response to 10mM quinine (Figure 1A), similar to our previous report (Ezak et al. 2010). Further, osm-9 and ocr-2 single mutants responded similarly to wild-type animals across the range of quinine concentrations tested (10mM - 1mM, Figure 1A). | Paper_evidence | WBPaper00059946 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Affected_by | Molecule | WBMol:00003904 | Paper_evidence | WBPaper00059946 | |||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001765 | Paper_evidence | WBPaper00031936 | |||||||
Curator_confirmed | WBPerson2021 | ||||||||
Remark | Mutants respond normally to CO2 | Paper_evidence | WBPaper00031936 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
EQ_annotations | Life_stage | WBls:0000057 | PATO:0000460 | Paper_evidence | WBPaper00031936 | ||||
Curator_confirmed | WBPerson2021 | ||||||||
Phenotype_assay | Treatment | 10% CO2 | Paper_evidence | WBPaper00031936 | |||||
Curator_confirmed | WBPerson2021 | ||||||||
WBPhenotype:0001939 | Paper_evidence | WBPaper00035961 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Affected_by | Molecule | WBMol:00003731 | Paper_evidence | WBPaper00035961 | |||||
Curator_confirmed | WBPerson712 | ||||||||
WBMol:00003904 | Paper_evidence | WBPaper00035961 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
WBMol:00003565 | Paper_evidence | WBPaper00035961 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
WBMol:00001530 | Paper_evidence | WBPaper00035961 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
WBMol:00005022 | Paper_evidence | WBPaper00035961 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Reference | WBPaper00038142 | ||||||||
WBPaper00031936 | |||||||||
WBPaper00031874 | |||||||||
WBPaper00035961 | |||||||||
WBPaper00025807 | |||||||||
WBPaper00058803 | |||||||||
WBPaper00059946 | |||||||||
WBPaper00045595 | |||||||||
WBPaper00064938 | |||||||||
WBPaper00064927 | |||||||||
Method | Deletion_allele |