WormBase Tree Display for Variation: WBVar00000111
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WBVar00000111 | Name | Public_name | ak10 | |||||
---|---|---|---|---|---|---|---|---|
Sequence_details | SeqStatus | Pending_curation | ||||||
Variation_type | Allele | |||||||
Origin | Species | Caenorhabditis elegans | ||||||
Strain | WBStrain00040170 | |||||||
WBStrain00040797 | ||||||||
Laboratory | VM | |||||||
Status | Live | |||||||
Affects | Gene | WBGene00001613 | ||||||
Genetics | Mapping_data | In_multi_point | 4355 | |||||
Description | Phenotype | WBPhenotype:0000249 | Person_evidence | WBPerson4875 | ||||
Curator_confirmed | WBPerson557 | |||||||
Remark | Eliminates the majority of fast glutamate-gated currents in AVA interneuron as assayed by patch clamp electrophysiology. Functions in complex with glr-1. Neuron (2002), v36, p933-944 | Person_evidence | WBPerson4875 | |||||
Curator_confirmed | WBPerson557 | |||||||
Penetrance | Complete | Person_evidence | WBPerson4875 | |||||
Curator_confirmed | WBPerson557 | |||||||
Dominant | Person_evidence | WBPerson4875 | ||||||
Curator_confirmed | WBPerson557 | |||||||
Variation_effect | Null | Person_evidence | WBPerson4875 | |||||
Curator_confirmed | WBPerson557 | |||||||
WBPhenotype:0000662 | Paper_evidence | WBPaper00006375 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | ARS defective. Animals do not exhibit a decrease in the frequency of high-angled turns in response to food deprivation. | Paper_evidence | WBPaper00006375 | |||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0001221 | Person_evidence | WBPerson4875 | ||||||
Curator_confirmed | WBPerson557 | |||||||
Remark | Nose touch response is subtle. Eliminates the majority of fast glutamate-gated currents in AVA interneuron as assayed by patch clamp electrophysiology. Functions in complex with glr-1. Neuron (2002), v36, p933-944 | Person_evidence | WBPerson4875 | |||||
Curator_confirmed | WBPerson557 | |||||||
Penetrance | Complete | Person_evidence | WBPerson4875 | |||||
Curator_confirmed | WBPerson557 | |||||||
Dominant | Person_evidence | WBPerson4875 | ||||||
Curator_confirmed | WBPerson557 | |||||||
Variation_effect | Null | Person_evidence | WBPerson4875 | |||||
Curator_confirmed | WBPerson557 | |||||||
WBPhenotype:0001444 | Paper_evidence | WBPaper00032335 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Animals showed defects in gustatory plasticity to NaCl compared to wild type. | Paper_evidence | WBPaper00032335 | |||||
Curator_confirmed | WBPerson712 | |||||||
Affected_by | Molecule | WBMol:00003571 | Paper_evidence | WBPaper00032335 | ||||
Curator_confirmed | WBPerson712 | |||||||
Phenotype_assay | Treatment | Animals were tested for response to 25 mM NaCl after various pre-treatments: a 15-min wash in CTX buffer with or without 100 mM NaCl (liquid), or 30 min on a CTX plate with or without 100 mM NaCl, and in the presence or absence of bacteria, 500 mM glycerol, or 3 uL of benzaldehyde. | Paper_evidence | WBPaper00032335 | ||||
Curator_confirmed | WBPerson712 | |||||||
Phenotype_not_observed | WBPhenotype:0000556 | Paper_evidence | WBPaper00006375 | |||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Animals modulated their ARS frequency of high-angled turns in the presence of exogenous dopamine in a manner similar to wild type. | Paper_evidence | WBPaper00006375 | |||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0001084 | Paper_evidence | WBPaper00031974 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Animals showed normal chemotaxis to NaCl in mock-conditioned assays and avoided NaCl just after conditioning. | Paper_evidence | WBPaper00031974 | |||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0001462 | Paper_evidence | WBPaper00032335 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Animals did not show defects in chemotaxis to NaCl compared to wild type. | Paper_evidence | WBPaper00032335 | |||||
Curator_confirmed | WBPerson712 | |||||||
Affected_by | Molecule | WBMol:00003571 | Paper_evidence | WBPaper00032335 | ||||
Curator_confirmed | WBPerson712 | |||||||
Phenotype_assay | Treatment | Animals were tested for response to 25 mM NaCl. | Paper_evidence | WBPaper00032335 | ||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0001785 | Paper_evidence | WBPaper00031974 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Animals retained the memory of the learned behavior; animals did not recover from the avoidance state rapidly. | Paper_evidence | WBPaper00031974 | |||||
Curator_confirmed | WBPerson712 | |||||||
Phenotype_assay | Treatment | Animals were subjected to a salt-chemotaxis-learning assay, in which starvation is paired with NaCl. | Paper_evidence | WBPaper00031974 | ||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0001817 | Paper_evidence | WBPaper00032335 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Animals exhibited enhanced-gustatory plasticity, i.e. strong avoidance to NaCl after starvation, similar to that observed for wild type. | Paper_evidence | WBPaper00032335 | |||||
Curator_confirmed | WBPerson712 | |||||||
Affected_by | Molecule | WBMol:00003571 | Paper_evidence | WBPaper00032335 | ||||
Curator_confirmed | WBPerson712 | |||||||
Reference | WBPaper00006375 | |||||||
WBPaper00032335 | ||||||||
WBPaper00031974 | ||||||||
Method | Allele |