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WormBase Tree Display for Variation: WBVar00000111

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Name Class

WBVar00000111NamePublic_nameak10
Sequence_detailsSeqStatusPending_curation
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00040170
WBStrain00040797
LaboratoryVM
StatusLive
AffectsGeneWBGene00001613
GeneticsMapping_dataIn_multi_point4355
DescriptionPhenotypeWBPhenotype:0000249Person_evidenceWBPerson4875
Curator_confirmedWBPerson557
RemarkEliminates the majority of fast glutamate-gated currents in AVA interneuron as assayed by patch clamp electrophysiology. Functions in complex with glr-1. Neuron (2002), v36, p933-944Person_evidenceWBPerson4875
Curator_confirmedWBPerson557
PenetranceCompletePerson_evidenceWBPerson4875
Curator_confirmedWBPerson557
DominantPerson_evidenceWBPerson4875
Curator_confirmedWBPerson557
Variation_effectNullPerson_evidenceWBPerson4875
Curator_confirmedWBPerson557
WBPhenotype:0000662Paper_evidenceWBPaper00006375
Curator_confirmedWBPerson712
RemarkARS defective. Animals do not exhibit a decrease in the frequency of high-angled turns in response to food deprivation.Paper_evidenceWBPaper00006375
Curator_confirmedWBPerson712
WBPhenotype:0001221Person_evidenceWBPerson4875
Curator_confirmedWBPerson557
RemarkNose touch response is subtle. Eliminates the majority of fast glutamate-gated currents in AVA interneuron as assayed by patch clamp electrophysiology. Functions in complex with glr-1. Neuron (2002), v36, p933-944Person_evidenceWBPerson4875
Curator_confirmedWBPerson557
PenetranceCompletePerson_evidenceWBPerson4875
Curator_confirmedWBPerson557
DominantPerson_evidenceWBPerson4875
Curator_confirmedWBPerson557
Variation_effectNullPerson_evidenceWBPerson4875
Curator_confirmedWBPerson557
WBPhenotype:0001444Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
RemarkAnimals showed defects in gustatory plasticity to NaCl compared to wild type.Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003571Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were tested for response to 25 mM NaCl after various pre-treatments: a 15-min wash in CTX buffer with or without 100 mM NaCl (liquid), or 30 min on a CTX plate with or without 100 mM NaCl, and in the presence or absence of bacteria, 500 mM glycerol, or 3 uL of benzaldehyde.Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000556Paper_evidenceWBPaper00006375
Curator_confirmedWBPerson712
RemarkAnimals modulated their ARS frequency of high-angled turns in the presence of exogenous dopamine in a manner similar to wild type.Paper_evidenceWBPaper00006375
Curator_confirmedWBPerson712
WBPhenotype:0001084Paper_evidenceWBPaper00031974
Curator_confirmedWBPerson712
RemarkAnimals showed normal chemotaxis to NaCl in mock-conditioned assays and avoided NaCl just after conditioning.Paper_evidenceWBPaper00031974
Curator_confirmedWBPerson712
WBPhenotype:0001462Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
RemarkAnimals did not show defects in chemotaxis to NaCl compared to wild type.Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003571Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were tested for response to 25 mM NaCl.Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
WBPhenotype:0001785Paper_evidenceWBPaper00031974
Curator_confirmedWBPerson712
RemarkAnimals retained the memory of the learned behavior; animals did not recover from the avoidance state rapidly.Paper_evidenceWBPaper00031974
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were subjected to a salt-chemotaxis-learning assay, in which starvation is paired with NaCl.Paper_evidenceWBPaper00031974
Curator_confirmedWBPerson712
WBPhenotype:0001817Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
RemarkAnimals exhibited enhanced-gustatory plasticity, i.e. strong avoidance to NaCl after starvation, similar to that observed for wild type.Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003571Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
ReferenceWBPaper00006375
WBPaper00032335
WBPaper00031974
MethodAllele