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WormBase Tree Display for Transgene: WBTransgene00010083

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Name Class

WBTransgene00010083Public_nameWBPaper00040471Is2
Summary[PH20::(h)Mo-Rho9; PH20::DsRed]
Synonym[N] (h)Mo
WBPaper00040471_Is2
ConstructionConstructWBCnstr00009731
Coinjection_otherPH20::DsRed
Integration_methodUV
Construction_summaryNeuronal expression of human melanopsin opsin (NP_150598.1).
Genetic_informationIntegrated
PhenotypeWBPhenotype:0000643Paper_evidenceWBPaper00040471
Curator_confirmedWBPerson712
RemarkWorms expressing (h)Mo in neurons were slightly hyperactive in locomotion.Paper_evidenceWBPaper00040471
Curator_confirmedWBPerson712
Caused_by_otherhuman melanopsinPaper_evidenceWBPaper00040471
Curator_confirmedWBPerson712
WBPhenotype:0001897Paper_evidenceWBPaper00040471
Curator_confirmedWBPerson712
RemarkAlthough worms expressing (h)Mo in neurons and pre-incubated with 9-cis-retinal failed to show any significant change in their rapid locomotion on light exposure, if these worms were incubated on the tracking plates seeded with OP50 bacteria for 2 h in dark before light stimulation, most worms slowed their motor activity during this period. On stimulation by blue light locomotion of worms preincubated with 10 uM 9-cis retinal but not control vehicle (no retinal), was enhanced. | [N] (h)Mo worms partially responded to preincubation with all-trans retinal.Paper_evidenceWBPaper00040471
Curator_confirmedWBPerson712
Caused_by_otherhuman melanopsinPaper_evidenceWBPaper00040471
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00005297Paper_evidenceWBPaper00040471
Curator_confirmedWBPerson712
WBMol:00004971Paper_evidenceWBPaper00040471
Curator_confirmedWBPerson712
ReferenceWBPaper00040471
SpeciesCaenorhabditis elegans