WormBase Tree Display for Transgene: WBTransgene00010083
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WBTransgene00010083 | Public_name | WBPaper00040471Is2 | ||||||
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Summary | [PH20::(h)Mo-Rho9; PH20::DsRed] | |||||||
Synonym | [N] (h)Mo | |||||||
WBPaper00040471_Is2 | ||||||||
Construction | Construct | WBCnstr00009731 | ||||||
Coinjection_other | PH20::DsRed | |||||||
Integration_method | UV | |||||||
Construction_summary | Neuronal expression of human melanopsin opsin (NP_150598.1). | |||||||
Genetic_information | Integrated | |||||||
Phenotype | WBPhenotype:0000643 | Paper_evidence | WBPaper00040471 | |||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Worms expressing (h)Mo in neurons were slightly hyperactive in locomotion. | Paper_evidence | WBPaper00040471 | |||||
Curator_confirmed | WBPerson712 | |||||||
Caused_by_other | human melanopsin | Paper_evidence | WBPaper00040471 | |||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0001897 | Paper_evidence | WBPaper00040471 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Although worms expressing (h)Mo in neurons and pre-incubated with 9-cis-retinal failed to show any significant change in their rapid locomotion on light exposure, if these worms were incubated on the tracking plates seeded with OP50 bacteria for 2 h in dark before light stimulation, most worms slowed their motor activity during this period. On stimulation by blue light locomotion of worms preincubated with 10 uM 9-cis retinal but not control vehicle (no retinal), was enhanced. | [N] (h)Mo worms partially responded to preincubation with all-trans retinal. | Paper_evidence | WBPaper00040471 | |||||
Curator_confirmed | WBPerson712 | |||||||
Caused_by_other | human melanopsin | Paper_evidence | WBPaper00040471 | |||||
Curator_confirmed | WBPerson712 | |||||||
Affected_by | Molecule | WBMol:00005297 | Paper_evidence | WBPaper00040471 | ||||
Curator_confirmed | WBPerson712 | |||||||
WBMol:00004971 | Paper_evidence | WBPaper00040471 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Reference | WBPaper00040471 | |||||||
Species | Caenorhabditis elegans |