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WormBase Tree Display for Transgene: WBTransgene00005887

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Name Class

WBTransgene00005887Public_nameqyIs15
Summary[zmp-1p::HA beta-tail]
ConstructionConstructWBCnstr00005755
Construction_summaryA dominant negative form of the C. elegans integrin expressed in the anchor cell.
Genetic_informationIntegrated
MapIV
PhenotypeWBPhenotype:0000104Paper_evidenceWBPaper00035117
Curator_confirmedWBPerson2021
RemarkAs levels of HA-btail increased, UNC-40, HIM-4, MIG-2 and PI(4,5)P2 failed to further concentrate at the invasive cell membrane and there was a loss of F-actin polarity. PAR-3 and AJM-1 localized normally in HA-btail animalsPaper_evidenceWBPaper00035117
Curator_confirmedWBPerson2021
WBPhenotype:0001652Paper_evidenceWBPaper00035117
Curator_confirmedWBPerson2021
RemarkComplete block in invasion at the P6.p four-cell stagePaper_evidenceWBPaper00035117
Curator_confirmedWBPerson2021
Phenotype_not_observedWBPhenotype:0000717Paper_evidenceWBPaper00035117
Curator_confirmedWBPerson2021
RemarkTranscriptional reporters for FOS-1A and all of its known targets were expressed normally in HA-btail animalsPaper_evidenceWBPaper00035117
Curator_confirmedWBPerson2021
ReferenceWBPaper00035117
WBPaper00038447
WBPaper00039950
WBPaper00044874
WBPaper00046146
WBPaper00050698
WBPaper00053373
SpeciesCaenorhabditis elegans