WormBase Tree Display for Transgene: WBTransgene00005885
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WBTransgene00005885 | Public_name | qyIs110 | |||||
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Summary | [egl-17p::HA beta-tail] | ||||||
Construction | Construct | WBCnstr00005753 | |||||
Construction_summary | A dominant negative integrin beta-subunit PAT-3 construct expresed in the vulD and neighbouring vulC cells driven by the egl-17 promoter. | ||||||
Genetic_information | Integrated | ||||||
Phenotype | WBPhenotype:0002066 | Paper_evidence | WBPaper00038447 | ||||
Curator_confirmed | WBPerson712 | ||||||
Remark | Expression of a dominant negative integrin beta-subunit PAT-3 construct in the vulD and neighboring vulC cells driven by the egl-17 promoter (egl-17>HA-beta-tail) resulted in a basement membrane gap overexpansion defect. | Blocking anchor cell invasion in animals expressing a dominant negative form of the C. elegans integrin specifically in the anchor cell resulted in a failure to generate a basement membrane gap (20/20 animals). | Paper_evidence | WBPaper00038447 | ||||
Curator_confirmed | WBPerson712 | ||||||
Caused_by_other | HA-beta tail | Paper_evidence | WBPaper00038447 | ||||
Curator_confirmed | WBPerson712 | ||||||
Phenotype_not_observed | WBPhenotype:0000220 | Paper_evidence | WBPaper00038447 | ||||
Curator_confirmed | WBPerson712 | ||||||
Remark | Animals did not have alterations in vulval fate specification. | Paper_evidence | WBPaper00038447 | ||||
Curator_confirmed | WBPerson712 | ||||||
Caused_by_other | HA-beta tail | Paper_evidence | WBPaper00038447 | ||||
Curator_confirmed | WBPerson712 | ||||||
WBPhenotype:0001652 | Paper_evidence | WBPaper00035117 | |||||
Curator_confirmed | WBPerson2021 | ||||||
Remark | Expression of HA-btail under the control of the egl-17 promoter did not affect AC invasion | Paper_evidence | WBPaper00035117 | ||||
Curator_confirmed | WBPerson2021 | ||||||
Reference | WBPaper00035117 | ||||||
WBPaper00038447 | |||||||
WBPaper00045383 | |||||||
Species | Caenorhabditis elegans |