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WormBase Tree Display for Transgene: WBTransgene00005885

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Name Class

WBTransgene00005885Public_nameqyIs110
Summary[egl-17p::HA beta-tail]
ConstructionConstructWBCnstr00005753
Construction_summaryA dominant negative integrin beta-subunit PAT-3 construct expresed in the vulD and neighbouring vulC cells driven by the egl-17 promoter.
Genetic_informationIntegrated
PhenotypeWBPhenotype:0002066Paper_evidenceWBPaper00038447
Curator_confirmedWBPerson712
RemarkExpression of a dominant negative integrin beta-subunit PAT-3 construct in the vulD and neighboring vulC cells driven by the egl-17 promoter (egl-17>HA-beta-tail) resulted in a basement membrane gap overexpansion defect. | Blocking anchor cell invasion in animals expressing a dominant negative form of the C. elegans integrin specifically in the anchor cell resulted in a failure to generate a basement membrane gap (20/20 animals).Paper_evidenceWBPaper00038447
Curator_confirmedWBPerson712
Caused_by_otherHA-beta tailPaper_evidenceWBPaper00038447
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000220Paper_evidenceWBPaper00038447
Curator_confirmedWBPerson712
RemarkAnimals did not have alterations in vulval fate specification.Paper_evidenceWBPaper00038447
Curator_confirmedWBPerson712
Caused_by_otherHA-beta tailPaper_evidenceWBPaper00038447
Curator_confirmedWBPerson712
WBPhenotype:0001652Paper_evidenceWBPaper00035117
Curator_confirmedWBPerson2021
RemarkExpression of HA-btail under the control of the egl-17 promoter did not affect AC invasionPaper_evidenceWBPaper00035117
Curator_confirmedWBPerson2021
ReferenceWBPaper00035117
WBPaper00038447
WBPaper00045383
SpeciesCaenorhabditis elegans