WormBase Tree Display for Transgene: WBTransgene00005872
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| WBTransgene00005872 | Public_name | wlzIs4 | ||||||
|---|---|---|---|---|---|---|---|---|
| Summary | [human LRRK2(G2019S)] | |||||||
| Construction | Construct | WBCnstr00005741 | ||||||
| Integration_method | Gamma_irradiation | |||||||
| Genetic_information | Integrated | |||||||
| Phenotype | WBPhenotype:0000179 | Paper_evidence | WBPaper00034758 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Remark | On reaching adulthood, the G2019S LRRK2; DAT::GFP line showed a significantly greater decrease in signal than control animals. Loss of fluorescence of a DAT::GFP construct is associated with degeneration of dopaminergic neurons | Paper_evidence | WBPaper00034758 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Caused_by_other | human LRRK2 mutant | Paper_evidence | WBPaper00034758 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| WBPhenotype:0000233 | Paper_evidence | WBPaper00034758 | ||||||
| Curator_confirmed | WBPerson2021 | |||||||
| Remark | The G2019S LRRK2/DAT::GFP line showed significantly less dopamine levels than control lines | Paper_evidence | WBPaper00034758 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Caused_by_other | human LRRK2 mutant | Paper_evidence | WBPaper00034758 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| WBPhenotype:0000459 | Paper_evidence | WBPaper00034758 | ||||||
| Curator_confirmed | WBPerson2021 | |||||||
| Remark | C. elegans expressing G2019S LRRK2 were resistant to rotenone and exhibited 40% survival at 8 days. DAT levels were similar to that of N2 after exposure to 250 nM rotenone for 24 h | Paper_evidence | WBPaper00034758 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Caused_by_other | human LRRK2 mutant | Paper_evidence | WBPaper00034758 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Phenotype_not_observed | WBPhenotype:0000061 | Paper_evidence | WBPaper00034758 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Remark | Transgenic lines exhibited lifespans similar to N2 strains | Paper_evidence | WBPaper00034758 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Caused_by_other | human LRRK2 mutant | Paper_evidence | WBPaper00034758 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| WBPhenotype:0000460 | Paper_evidence | WBPaper00034758 | ||||||
| Curator_confirmed | WBPerson2021 | |||||||
| Remark | G2019S LRRK2 did not protect C. elegans against paraquat and gave a profile similar to that of N2 | Paper_evidence | WBPaper00034758 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Caused_by_other | human LRRK2 mutant | Paper_evidence | WBPaper00034758 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Affected_by | Molecule | WBMol:00002747 | Paper_evidence | WBPaper00034758 | ||||
| Curator_confirmed | WBPerson2021 | |||||||
| Reference | WBPaper00034758 | |||||||
| WBPaper00040571 | ||||||||
| Species | Caenorhabditis elegans |
