WormBase Tree Display for Transgene: WBTransgene00004665
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| WBTransgene00004665 | Public_name | syIs25 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Summary | [pJM3QL + pMH86] | ||||||||
| Synonym | [gpa-3::gpa-3(QL)] | ||||||||
| gpa-3QL | |||||||||
| Construction | Construct | WBCnstr00004647 | |||||||
| Construction_summary | QL means a constitutive activating mutation. | ||||||||
| Genetic_information | Integrated | ||||||||
| Map | X | ||||||||
| Map_evidence | Paper_evidence | WBPaper00029060 | |||||||
| Phenotype (15) | |||||||||
| Phenotype_not_observed | WBPhenotype:0000679 | Paper_evidence | WBPaper00048972 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Remark | "Next, we tested whether gpa-3QL affects GFP::RAB-5. Interestingly, in gpa-3QL(syIs25) animals GFP::RAB-5 fluorescence intensity was reduced both at the dendritic ending and in the cell body (Fig 6A), although quantification of the fluorescence intensities did not reveal a significant difference between wild type and gpa-3QL animals (Fig 6D and 6E). However, these results are in accordance with the hypothesis that endocytosis is affected in gpa-3QL animals." | Paper_evidence | WBPaper00048972 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Caused_by_gene | WBGene00001665 | Paper_evidence | WBPaper00048972 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Phenotype_assay | Genotype | GFP::RAB-5 | Paper_evidence | WBPaper00048972 | |||||
| Curator_confirmed | WBPerson2987 | ||||||||
| WBPhenotype:0001414 | Paper_evidence | WBPaper00003465 | |||||||
| Curator_confirmed | WBPerson291 | ||||||||
| Caused_by_gene | WBGene00001665 | Paper_evidence | WBPaper00003465 | ||||||
| Curator_confirmed | WBPerson291 | ||||||||
| WBPhenotype:0001780 | Paper_evidence | WBPaper00029060 | |||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Remark | Mutants show normal butanone enhancement | Paper_evidence | WBPaper00029060 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Caused_by_gene | WBGene00001665 | Paper_evidence | WBPaper00029060 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Variation_effect | Hypermorph_gain_of_function | Paper_evidence | WBPaper00029060 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| EQ_annotations | Life_stage | WBls:0000057 | PATO:0000460 | Paper_evidence | WBPaper00029060 | ||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Phenotype_assay | Treatment | Preexposure to 1:10 dilution of butanone and food. Animals were then subjected to odorant chemotaxis assays and/or selection assays | Paper_evidence | WBPaper00029060 | |||||
| Curator_confirmed | WBPerson2021 | ||||||||
| WBPhenotype:0002096 | Paper_evidence | WBPaper00042072 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | In gpa-3QL animals we observed distinct AMAN-2 structures similar to those observed in wild type animals. | Paper_evidence | WBPaper00042072 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Caused_by_gene | WBGene00001665 | Paper_evidence | WBPaper00042072 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Used_for | Interactor | WBInteraction000051447 | |||||||
| WBInteraction000051449 | |||||||||
| WBInteraction000503995 | |||||||||
| WBInteraction000503996 | |||||||||
| WBInteraction000503997 | |||||||||
| WBInteraction000534876 | |||||||||
| WBInteraction000534877 | |||||||||
| WBInteraction000534878 | |||||||||
| WBInteraction000534879 | |||||||||
| WBInteraction000534880 | |||||||||
| Associated_with | Strain | WBStrain00030854 | |||||||
| Reference | WBPaper00003465 | ||||||||
| WBPaper00028950 | |||||||||
| WBPaper00029060 | |||||||||
| WBPaper00033456 | |||||||||
| WBPaper00035927 | |||||||||
| WBPaper00036302 | |||||||||
| WBPaper00042072 | |||||||||
| WBPaper00048972 | |||||||||
| Species | Caenorhabditis elegans |
