WormBase Tree Display for Transgene: WBTransgene00000410
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| WBTransgene00000410 | Public_name | dvIs2 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Summary | [Punc-54::human Beta-peptide 1-42 minigene+ pRF4] | ||||||||
| Synonym | [Punc-54::A beta 3-42; pRF4 (rol-6 (su1006)] | ||||||||
| [Punc-54::beta-peptide; pRF4] | |||||||||
| [pCL12(unc-54/Ab 1-42) pRF4(su1006)] | |||||||||
| Construction | Construct | WBCnstr00000410 | |||||||
| Coinjection | WBCnstr00004720 | ||||||||
| Integration_method | Gamma_irradiation | ||||||||
| Construction_summary | Beta-peptide is the primary biochemical component that forms beta-amyloid. Ex transmitting line: CL1019. | ||||||||
| Genetic_information | Integrated | ||||||||
| Map | II | ||||||||
| Phenotype | WBPhenotype:0001236 | Paper_evidence | WBPaper00056554 | ||||||
| Curator_confirmed | WBPerson5649 | ||||||||
| Remark | expression of mgIs72[rpt-3::gfp] transgene increased in body wall muscles | Paper_evidence | WBPaper00056554 | ||||||
| Curator_confirmed | WBPerson5649 | ||||||||
| Caused_by_other | Amyloid beta(1-42) | Paper_evidence | WBPaper00056554 | ||||||
| Curator_confirmed | WBPerson5649 | ||||||||
| EQ_annotations | Anatomy_term | WBbt:0006804 | PATO:0000460 | Paper_evidence | WBPaper00056554 | ||||
| Curator_confirmed | WBPerson5649 | ||||||||
| Phenotype_assay | Control_strain | WBStrain00007961 | Paper_evidence | WBPaper00056554 | |||||
| Curator_confirmed | WBPerson5649 | ||||||||
| Genotype | mgIs72 [rpt-3::gfp] | Paper_evidence | WBPaper00056554 | ||||||
| Curator_confirmed | WBPerson5649 | ||||||||
| Phenotype_not_observed | WBPhenotype:0002529 | Paper_evidence | WBPaper00056554 | ||||||
| Curator_confirmed | WBPerson5649 | ||||||||
| Remark | proteasome function was not impaired in body wall muscle cells. Animals carrying the dvIs2 transgene did not show stabilization of ub(G76V)::GFP in muscle cells. | Paper_evidence | WBPaper00056554 | ||||||
| Curator_confirmed | WBPerson5649 | ||||||||
| Caused_by_other | Amyloid beta(1-42) | Paper_evidence | WBPaper00056554 | ||||||
| Curator_confirmed | WBPerson5649 | ||||||||
| EQ_annotations | Anatomy_term | WBbt:0006804 | PATO:0000460 | Paper_evidence | WBPaper00056554 | ||||
| Curator_confirmed | WBPerson5649 | ||||||||
| Phenotype_assay | Control_strain | WBStrain00007977 | Paper_evidence | WBPaper00056554 | |||||
| Curator_confirmed | WBPerson5649 | ||||||||
| Genotype | mgIs77 [Prpl-28::Ub(G76V)::GFP] | Paper_evidence | WBPaper00056554 | ||||||
| Curator_confirmed | WBPerson5649 | ||||||||
| Associated_with | Strain | WBStrain00000200 | |||||||
| WBStrain00000203 | |||||||||
| WBStrain00005094 | |||||||||
| WBStrain00005093 | |||||||||
| Component_of_genotype | WBGenotype00000136 | ||||||||
| WBGenotype00000137 | |||||||||
| WBGenotype00000138 | |||||||||
| WBGenotype00000139 | |||||||||
| WBGenotype00000148 | |||||||||
| Reference (75) | |||||||||
| Species | Caenorhabditis elegans |
