WormBase Tree Display for Transgene: WBTransgene00000040

WBTransgene00000040 Public_name: arIs12
  Summary: [lin-12(intra)]
  Synonym: Is[lin-12(intra)]
    arIs1
  Construction: Construct: WBCnstr00000040
  Construction_summary: Maps between dpy-5 and unc-13. Integration method = irradiation (Struhl et al., 1993).
    Expresses the intracellular domain of LIN-12 under the control of lin-12 promoter. Marked with rol-6(su1006).
  Genetic_information: Integrated
    Map: I
    Phenotype: WBPhenotype:0000006 Paper_evidence: WBPaper00001778
        Curator_confirmed: WBPerson712
        Remark: Animals exhibited a highly penetrant Egl phenotype at all temperatures; occasionally non-Egl animals were seen. Paper_evidence: WBPaper00001778
            Curator_confirmed: WBPerson712
        Caused_by_gene: WBGene00003001 Paper_evidence: WBPaper00001778
            Curator_confirmed: WBPerson712
      WBPhenotype:0000216 Paper_evidence: WBPaper00001778
        Curator_confirmed: WBPerson712
        Remark: Animals lack an AC, presumably Zl .ppp and Z4.aaa become VUs. Paper_evidence: WBPaper00001778
            Curator_confirmed: WBPerson712
        Caused_by_gene: WBGene00003001 Paper_evidence: WBPaper00001778
            Curator_confirmed: WBPerson712
      WBPhenotype:0000414 Paper_evidence: WBPaper00001778
        Curator_confirmed: WBPerson712
        Remark: Dorsal coelomocytes appear to be transformed into dorsal sex myoblasts; P9.p in males generates descendants with a hook, which is normally a fate of P10.p descendants. Higher doses of lin-12 result in P11.p descendants generating a hook in the P9.p location. Paper_evidence: WBPaper00001778
            Curator_confirmed: WBPerson712
        Caused_by_gene: WBGene00003001 Paper_evidence: WBPaper00001778
            Curator_confirmed: WBPerson712
      WBPhenotype:0000696 Paper_evidence: WBPaper00001778
        Curator_confirmed: WBPerson712
        Caused_by_gene: WBGene00003001 Paper_evidence: WBPaper00001778
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: Paper_evidence: WBPaper00001778
              Curator_confirmed: WBPerson712
        Phenotype_assay: Temperature: 25 Paper_evidence: WBPaper00001778
              Curator_confirmed: WBPerson712
      WBPhenotype:0000700 Paper_evidence: WBPaper00001778
        Curator_confirmed: WBPerson712
        Remark: The temperature-sensitive period for the Multivulva phenotype caused by this transgene is in the early third larval stage, before the VPCs divide, that is, when VPC fates are determined. Paper_evidence: WBPaper00001778
            Curator_confirmed: WBPerson712
        Caused_by_gene: WBGene00003001 Paper_evidence: WBPaper00001778
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Cold_sensitive: Paper_evidence: WBPaper00001778
              Curator_confirmed: WBPerson712
        Phenotype_assay: Temperature: 15 Paper_evidence: WBPaper00001778
              Curator_confirmed: WBPerson712
      WBPhenotype:0001276 Paper_evidence: WBPaper00001778
        Curator_confirmed: WBPerson712
        Remark: Ectopic expression of lin-11::LacZ in VPC descendants indicating ectopic expression of a secondary fate in the VPCs. Paper_evidence: WBPaper00001778
            Curator_confirmed: WBPerson712
        Caused_by_gene: WBGene00003001 Paper_evidence: WBPaper00001778
            Curator_confirmed: WBPerson712
      WBPhenotype:0001305 Paper_evidence: WBPaper00001778
        Curator_confirmed: WBPerson712
        Remark: Males frequently had at least one ectopic hook. Paper_evidence: WBPaper00001778
            Curator_confirmed: WBPerson712
        Caused_by_gene: WBGene00003001 Paper_evidence: WBPaper00001778
            Curator_confirmed: WBPerson712
  Reference (11)
  Species: Caenorhabditis elegans