WormBase Tree Display for RNAi: WBRNAi00101914

WBRNAi00101914 Homol: Homol_homol: F18E9:RNAi
  Sequence_info: PCR_product: sjj_F18E9.2
  Experiment: Laboratory: IZ
    Date: 18 Jul 2014 00:00:00
    Genotype: L-AChR(gf) (ufIs6)
    Temperature: 20
    Delivered_by: Bacterial_feeding
  Inhibits: Predicted_gene: F18E9.2b Inferred_automatically: RNAi_primary
      F18E9.2a Inferred_automatically: RNAi_primary
    Gene: WBGene00003745 Inferred_automatically: RNAi_primary
    Transcript: F18E9.2b.1 Inferred_automatically: RNAi_primary
      F18E9.2a.1 Inferred_automatically: RNAi_primary
  Species: Caenorhabditis elegans
  Interaction: WBInteraction000523934
  Reference: WBPaper00045671
  Phenotype: WBPhenotype:0000643 Remark: This RNAi was able to suppress the locomotion phenotypes found in L-AChR(gf) animals. L-AChR(gf) enhances synaptic activation of muscles by increasing L-AChR function.
  Remark: The authors wanted to enhance synaptic activation of muscles by increasing L-AChR function, thus they introduced an amino acid change at a highly conserved position in the pore-lining M2 regions of cDNAs encoding the UNC-29, UNC-38 and LEV-1 subunits. They constructed a strain (ufIs6) stably expressing the unc-29(L/S), unc-38(V/S) and lev-1(L/S) cDNAs under control of the muscle-specific myo-3 promoter, and refer to this as L-AChR(gf).
  Method: RNAi