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| WBPicture0000012289 | Description | The RING Domain of Mdm2 Alters the Stability of GFP in C. elegans (A) The RING domain of Mdm2 reduces the number of cells expressing GFP from the unc-4 promoter. Animals expressing GFP, the wild-type Mdm2 RING domain fused to GFP, and the K454A Mdm2 RING domain fused to GFP were synchronized by bleaching gravid adults and observing the remaining newly hatched larvae. The number of GFP-expressing cells (regardless of intensity) was counted at the indicated times (n8). Each numbered line represents data from a different stable line. Note that the number of cells expressing GFP alone increases as animals age. The number of cells decreases when the RING domain is included. (B) Examples of 48 hr posthatching adults. Adults expressing GFP alone (top panels), the wild-type Mdm2 RING domain fused to GFP(middle panels), and the K454A Mdm2 RING domain fused to GFP (bottom panels). | |||
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| Name | FigD.jpg | ||||
| Crop | Crop_picture | WBPicture0000012290 | |||
| Acknowledgment | Template | Reprinted from <Journal_URL>, <Article_URL>, Copyright <Publication_year>, with permission from <Publisher_URL>. | |||
| Publication_year | 2003 | ||||
| Article_URL | DOI | id | 10.1016/S1097-2765(03)00400-3 | ||
| Journal_URL | MolecularCell | ||||
| Publisher_URL | Elsevier | ||||
| Reference | WBPaper00006176 |
