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| WBPicture0000010851 | Description | Figure 2. Molecular structure of sor-3 and its expression pattern. (A) Cosmid C04E7 and the PCR fragment containing C04E7.2 can fully rescue the mutant defects in sor-3, whereas the neighboring cosmids F52D1, ZK1193, M02E1, and F38G1 cannot rescue the sor-3 mutant defects. The cDNA sequence of sor-3 was confirmed by sequencing RT-PCR products. Sixty-three base pairs in the predicted sor-3 gene are not present in our cDNAs. The length of the introns and exons is not to scale. (B) Protein sequence of SOR-3. sor-3(bp185) contains a glutamine to stop-codon mutation, deleting the C-terminal 62 aa. The MBT domain is marked in blue. (C) Alignment of the MBT domains found in SOR-3, mouse PcG protein Sfmbt, and fly PcG proteins Sex combs on midleg (SCM). The identical amino acids found in the SOR-3 MBT domain and at least in one other MBT domain are highlighted. (D and E) Expression of sor-3::gfp in developing embryos (D) and larvae (E). sor-3 is expressed in all cells examined. (F) SOR-3 is localized in both nucleus and cytoplasm but excluded from nucleolus. | |||
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| Name | F2.large.jpg | ||||
| Remark | Not expressed in the nucleolus. | ||||
| Depict | Expr_pattern | Expr4499 | |||
| Anatomy | WBbt:0004017 | ||||
| Cellular_component | GO:0005634 | ||||
| GO:0005737 | |||||
| Acknowledgment | Template | Reprinted with permission from <Journal_URL> <Article_URL>. Copyright (<Publication_year>), <Publisher_URL>. | |||
| Publication_year | 2007 | ||||
| Article_URL | DOI | id | 10.1073/pnas.0610261104 | ||
| Journal_URL | ProcNatlAcadSciUSA | ||||
| Publisher_URL | NationalAcademyofSciencesUSA | ||||
| Reference | WBPaper00028988 |
