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| WBPicture0000010722 | Description | Figure 3. Identification of TAX-6 as a target and a positive regulator of DAF-2 signaling. (A to F) TAX-6::GFP was expressed in neurons (open arrows) and in the cytoplasm (solid arrows) and nucleus (arrowheads) of intestinal cells. tax-6(p675); Ex[pAK13] animals were imaged at magnifications 100 [(A) to (C)] and 400 [(D) to (F)]. DIC, differential interference contrast. (G) Expression of TAX-6::GFP in the intestine of animals treated with control, daf-2, or tax-6 RNAi. The intensity of cytoplasmic and nuclear TAX-6::GFP in the intestine was scored separately. Percentages of worms expressing strong (+++), intermediate (++), weak (+), very weak (+/-), or background (-) TAX-6::GFP in the intestine were averaged from three experiments (n > 39 animals in each experiment). (H) Effects of the tax-6(p675) mutation on dauer formation and a synthetic effect with daf-2 RNAi. WT ('1' and '2'), daf-16 (mu86) ('3' and '4'), and tax-6(p675) ('5' and '6') animals were treated with daf-2 ('2,''4,' and '6') or control RNAi ('1,''3,' and '5') at 27C (black, one experiment) or 25C (gray, average of two experiments) (n &gt; 120 animals in each experiment). (I) daf-16(mu86) suppressed tax-6(p675) dauer formation (average of two experiments, n &gt; 300 animals per experiment). (J) daf-16(mu86) suppressed the long life span of tax-6(p675) mutant animals (one experiment, n > 80 animals, P &lt; 0.01, log-rank test). (K) cnb-1 mutants displayed an extended life span (one experiment, n > 80 animals, P < 0.01, log-rank test). | |||
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| Name | F3.large.jpg | ||||
| Crop | Crop_picture | WBPicture0000010723 | |||
| Acknowledgment | Template | From <Article_URL>. Reprinted with permission from <Publisher_URL>. Readers may view, browse, and/or download material for temporary copying purposes only, provided these uses are for noncommercial personal purposes. Except as provided by law, this material may not be further reproduced, distributed, transmitted, modified, adapted, performed, displayed, published, or sold in whole or in part, without prior written permission from the publisher. | |||
| Publication_year | 2007 | ||||
| Article_URL | DOI | id | 10.1126/science.1139952 | ||
| Journal_URL | Science | ||||
| Publisher_URL | AAAS | ||||
| Reference | WBPaper00030894 |
