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| WBPicture0000009750 | Description | Figure 4. Localization and Function of UNC-75-like RRM Proteins. (A and B) Cellular and subcellular localization of UNC-75 superfamily members in C. elegans. Proteins were expressed in transgenic animals as GFP fusion proteins (schematically shown above each panel). Between 4 and 11 transgenic lines were analyzed for each construct. (A) The ELAV ortholog EXC-7/F35H8.5 localizes to the head (upper left panel; corresponding Nomarski image, upper right panel), to ventral cord neuron nuclei (lower left panel, arrows), and to subnuclear speckles within the nuclei (lower right panel, arrows). Note that the number of neuronal head nuclei that express EXC-7::GFP is limited (upper left panel), which is consistent with the previous notion of nonubiquitous neuronal expression of this gene [29]. (B) The hnRNP F/H ortholog W02D3.11 localizes to subnuclear speckles (arrow) in all embryonic cells.(C) Synaptic transmission defects in exc-7(rh252) mutants. Animals were cultivated at 15 C, and assays for paralysis were done on 1 mM aldicarb at 15 C. The graph represents the average and SEM of four trials for each genotype. | |||
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| Name | F4.jpg | ||||
| Crop | Crop_picture | WBPicture0000009751 | |||
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| Acknowledgment | Template | Reprinted from <Journal_URL>, <Article_URL>, Copyright <Publication_year>, with permission from <Publisher_URL>. | |||
| Publication_year | 2003 | ||||
| Article_URL | DOI | id | 10.1016/S0960-9822(03)00532-3 | ||
| Journal_URL | CurrentBiology | ||||
| Publisher_URL | Elsevier | ||||
| Reference | WBPaper00006029 |
