WormBase Tree Display for Interaction: WBInteraction000569151
expand all nodes | collapse all nodes | view schema
| WBInteraction000569151 | Interaction_type | Genetic | Suppression | ||
|---|---|---|---|---|---|
| GI_module_two | Suppressing | ||||
| Interactor | Interactor_overlapping_gene | WBGene00000042 | Interactor_type | Affected | |
| Molecule_interactor | WBMol:00003915 | Interactor_type | Effector | ||
| Variation_interactor | WBVar00090467 | Interactor_type | Affected | ||
| Interaction_summary | Quote from paper: "As arecoline is a cholinergic agonist and may likely induce parallel elevation of cholinergic signaling, we expected to observe an enhancement of acr-2(gf) phenotypes. However, to our surprise, arecoline treatment strongly suppressed the convulsion rate of acr-2(gf) animals. We observed a dose-dependent suppression of convulsion after 3hrs of arecoline treatment (Figure 1A). The Unc phenotype of these animals was also strongly suppressed, with animals moving rapidly across the plate following drug treatment. This effect of arecoline is reversible, and the convulsion phenotype almost fully recovered after 1hr off drug (Figure 1B)." | ||||
| Throughput | Low_throughput | ||||
| Interaction_phenotype | WBPhenotype:0001701 | ||||
| WBPhenotype:0000643 | |||||
| Paper | WBPaper00059879 | ||||
| Remark | Figure 1 |
