WormBase Tree Display for Interaction: WBInteraction000556881

WBInteraction000556881 Interaction_type: Regulatory: Change_of_localization
  Interactor: Interactor_overlapping_gene: WBGene00004897 Interactor_type: Trans_regulated
        Transgene: WBTransgene00000707
        Construct: WBCnstr00000703
      WBGene00004719 Interactor_type: Trans_regulator
    Variation_interactor: WBVar00088437 Interactor_type: Trans_regulator
  Interaction_summary: "We isolated six alleles (ky281, ky289, ky326, ky330, ky332, and ky344) of sad-1 in the Pstr-3::SNB-1::GFP screen, and a seventh allele (ju52) in a similar type of screen using Punc-25::SNB-1::GFP (see below). All alleles displayed highly penetrant SNB-1::GFP defects in ASI, with over 90% of animals exhibiting a visible defect. The spectrum of defects included regions of the axon that appeared to lack vesicle clusters (Figures 2C and 2D); regions of the axon with densely packed vesicle clusters (Figures 2E and 2F); vesicle clusters that were irregular in size, orften appearing smaller than normal (Figures 2E and 2F and data not shown); and axons that displayed diffuse SNB-1::GFP fluorescence (Figures 2G and 2H)."
  Detection_method: Construct
    Reporter_gene: [unc-25p::SNB-1::GFP]
    Transgene
  Regulation_level: Post_translational
  Regulation_result: Positive_regulate: Anatomy_term: WBbt:0005666
      Subcellular_localization: synaptic vesicles
  Paper: WBPaper00004523
  Remark: Fig. 2