WormBase Tree Display for Interaction: WBInteraction000555607
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| WBInteraction000555607 | Interaction_type | Regulatory | Change_of_localization | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00004766 | Interactor_type | Trans_regulator | |
| WBGene00001609 | Interactor_type | Trans_regulated | |||
| Variation_interactor | WBVar00000221 | Interactor_type | Trans_regulator | ||
| Interaction_summary | "In the germline of glp-1(q415) hermaphrodites... GLP-1(q415) does not display the honeycomb pattern, and instead accumulates within the cell, consistent with a defect in its transport to the plasma membrane. In contrast, in the germline of glp-1(q415); sel-9(ar174) hermaphrodites, plasma membrane accumulation of GLP-1(q415) is at least partially restored, as a honeycomb pattern is evident. These results suggest that the absence of sel-9 activity relieves the block on trafficking of mutant GLP-1(q415) protein to the plasma membrane." | ||||
| Regulation_level | Post_translational | ||||
| Regulation_result | Negative_regulate | Life_stage | WBls:0000041 | ||
| Anatomy_term | WBbt:0005784 | ||||
| Subcellular_localization | plasma membrane | ||||
| Paper | WBPaper00003577 | ||||
| Remark | Fig. 5; glp-1(q415) mutant background |
