WormBase Tree Display for Interaction: WBInteraction000554889
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| WBInteraction000554889 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00003224 | Interactor_type | Trans_regulator | |
| WBGene00002957 | Interactor_type | Trans_regulated | |||
| Variation_interactor | WBVar00000479 | Interactor_type | Trans_regulator | ||
| Interaction_summary | "We found in this assay that mutations in four of the mes genes, mes-2, mes-3, mes-4 and mes-6, resulted in desilencing of the transgene array, as evidenced by the expression of the transgene array in the residual germ cells (Fig. 2). The observed desilencing was temporally limited; activation was most dramatically seen in adult animals, and was only rarely observed in late (L4) larvae (not shown). Germline transgene activity was not observed in earlier larval stages (L1,L2,L3). In adults, we observed a regional preference for accumulation of the transgene product, with activity frequently restricted to the medial region of each gonad arm (Fig. 2B)." | ||||
| Detection_method | Reporter_gene | [let-858::gfp] | |||
| Regulation_result | Negative_regulate | Life_stage | WBls:0000041 | ||
| Anatomy_term | WBbt:0005175 | ||||
| Paper | WBPaper00003143 | ||||
| Remark | Fig. 2 |
