WormBase Tree Display for Interaction: WBInteraction000544070
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| WBInteraction000544070 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00004932 | Interactor_type | Trans_regulated | |
| Other_interactor | Staphylococcus aureus infection | Interactor_type | Trans_regulator | ||
| Interaction_summary | "In the absence of UE-12, spp-1 and dod-22 were downregulated (2-3-fold), mtl-1 was upregulated (~2.5-fold) whilst sod-3 was unaffected (Fig. 5C). In infected worms treated with UE-12, all four genes were significantly induced by 3.3-7.5-fold (p<0.05) (Fig. 5C), indicating that UE-12 was able to boost the expression of DAF-16-regulated genes. To confirm that the modulation of these genes require the presence of DAF-16, we profiled the expression of all four DAF-16 targets as well as lys-7 (Fig. 1H) in the daf-16 (mu86) mutant background. No significant difference was observed in the expression of these genes in both treated and untreated daf-16 mutant animals (Fig. 5D)." | ||||
| Detection_method | RT_PCR | ||||
| Regulation_level | Transcriptional | ||||
| Regulation_result | Does_not_regulate | Life_stage | WBls:0000041 | ||
| Paper | WBPaper00045438 | ||||
| Remark | Fig. 5c |
