WormBase Tree Display for Interaction: WBInteraction000542785
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| WBInteraction000542785 | Interaction_type | Regulatory | Change_of_localization | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00000898 | Interactor_type | Trans_regulator | |
| WBGene00000912 | Interactor_type | Trans_regulated | |||
| Interaction_summary | "we examined whether NT219 modulates the cellular localization of DAF-16. Worms that express GFP-tagged DAF-16 under the regulation of the daf-16 promoter (strain TJ356) were left untreated (EV), exposed to the vehicle or treated with NT219 for 3 h. An identical group of worms was treated with daf-2 RNAi. Visualization indicated that unlike in untreated and vehicle-exposed worms, DAF-16 enters the nuclei as a result of NT219 treatment and exposure to daf-2 RNAi (Fig. 2G, arrows). These observations confirm that NT219 attenuates the IIS." | ||||
| Detection_method | Reporter_gene | [daf-16p::gfp] | |||
| Regulation_level | Transcriptional | ||||
| Regulation_result | Positive_regulate | Life_stage | WBls:0000041 | ||
| Subcellular_localization | nucleus | ||||
| Paper | WBPaper00044508 | ||||
| Remark | Fig. 2g |
