WormBase Tree Display for Interaction: WBInteraction000542639
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WBInteraction000542639 | Interaction_type | Regulatory | Change_of_expression_level | ||
---|---|---|---|---|---|
Interactor | Interactor_overlapping_gene | WBGene00000183 | Interactor_type | Trans_regulator | |
WBGene00004932 | Interactor_type | Trans_regulated | |||
WBGene00001752 | Interactor_type | Trans_regulated | |||
Interaction_summary | "We observe the greatest degree of regulation, however, amongst the 16 regulators of cytoprotective gene expression that regulate 2 or more of the tested cytoprotective pathways. lin-40 gene inactivation disrupts psod-3::gfp induction 17-fold, and pgst-4::gfp 2-fold. let-92 gene inactivation results in the most potent disruption of pgst-4::gfp induction, decreasing expression 25-fold, and inhibiting induction of psod-3::gfp and phsp-6::gfp by 3- and 4-fold, respectively. ima-3 and elt-2 gene inactivations both dramatically decrease induction of phsp-6::gfp by antimycin. ima-3 gene inactivation additionally inhibits the induction of pgst-4::gfp (4-fold). elt-2, like let-70 and cpsf-2, is required for the appropriate regulation of all four tested cytoprotective pathways (Table 1, Figure 1)." | ||||
Detection_method | Reporter_gene | [sod-3p::gfp], [gst-4p::gfp] | |||
Regulation_level | Transcriptional | ||||
Paper | WBPaper00041330 | ||||
Remark | Table 1, Fig. 1 |