WormBase Tree Display for Interaction: WBInteraction000542385
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| WBInteraction000542385 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00004799 | Interactor_type | Trans_regulator | |
| WBGene00000833 | Interactor_type | Trans_regulated | |||
| WBGene00001509 | Interactor_type | Trans_regulated | |||
| WBGene00002010 | Interactor_type | Trans_regulated | |||
| WBGene00004932 | Interactor_type | Trans_regulated | |||
| Interaction_summary | "Similar to compounds that boost NAD+ levels, sir-2.1 overexpression did not affect the daf-16 gene expression, but increased expression of mitochondrial regulators cts-1 and fzo-1, the daf-16 target sod-3, and the expression of the UPRmt gene hsp-6, without changes in other stress markers, such as hsp-4, hsf-1, sod-1, sod-2, gst-4, and prdx-2 (Figure 5C)." | ||||
| Detection_method | RT_PCR | ||||
| Regulation_level | Transcriptional | ||||
| Paper | WBPaper00043942 | ||||
| Remark | Fig. 5C; MV398: sir-2.1 overexpression transgenic worm |
