WormBase Tree Display for Interaction: WBInteraction000541616
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| WBInteraction000541616 | Interaction_type | Regulatory | |||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00001985 | Interactor_type | Trans_regulator | |
| WBGene00004769 | Interactor_type | Trans_regulator | |||
| WBGene00000148 | Interactor_type | Trans_regulated | |||
| Interaction_summary | In wild-type 4-cell stage embryos, the APH-2 protein is associated with the surface membranes of all four cells. Presenilin-deficient embryos (sel-12(ty11); hop-1(RNAi) showed an abnormal accumulation of APH-2 around the nucleus in an apparently identical pattern to that of aph-1 mutant embryos. (see Gene_regulation cgc5082_aph-2.a). | ||||
| Regulation_result | Negative_regulate | Subcellular_localization | endoplasmic reticulum | ||
| Paper | WBPaper00005082 | ||||
| Antibody_remark | Anti APH-2 antibody. |
