WormBase Tree Display for Interaction: WBInteraction000536031
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| WBInteraction000536031 | Interaction_type | Genetic | Suppression | ||
|---|---|---|---|---|---|
| GI_module_two | Suppressing | ||||
| Interactor | Interactor_overlapping_gene | WBGene00022832 | Interactor_type | Effector | |
| WBGene00000898 | Interactor_type | Affected | |||
| WBGene00000102 | Interactor_type | Affected | |||
| Variation_interactor | WBVar00143949 | Interactor_type | Affected | ||
| WBVar00091812 | Interactor_type | Affected | |||
| Interaction_summary | "Using dauer formation as the readout, we performed genetic epistasis experiments to identify the substrate of PDP-1. We first tested whether pdp-1 acted directly through the IIS pathway by focusing on kinase mutants downstream of daf-2 (Table 1 and Figure S9). pdk-1(sa680), daf-2(e1370); akt-1(ok525) and daf-2(e1370); akt-2(ok393) mutants were maintained on vector, daf-18 and pdp-1 RNAi and dauer formation of these strains was assayed at the appropriate temperatures. Interestingly, pdp-1 RNAi resulted in suppression of dauer formation of pdk-1(sa680) mutants, daf-2(e1370); akt-1(ok525) and daf-2(e1370); akt-2(ok393) worms (Table 1 and Figure S9)." | ||||
| Throughput | Low_throughput | ||||
| Interaction_RNAi | WBRNAi00108063 | ||||
| Interaction_phenotype | WBPhenotype:0000637 | ||||
| Paper | WBPaper00038374 | ||||
| Remark | Table 1, Figure S9 |
