WormBase Tree Display for Interaction: WBInteraction000534831
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WBInteraction000534831 | Interaction_type | Regulatory | Change_of_expression_level | |
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Interactor (2) | ||||
Interaction_summary | Wild-type worms induce the intestinal expression of a gcs-1::gfp transcriptional reporter within 5 hours of infection with PA14 (One-way ANOVA, F = 13.33; Tukey HSD test, P<0.01)(Fig 3A, 3B and 3E). Note that this change in gene expression occurs rapidly, before visible physical symptoms appear. In contrast, fshr-1(ok778) mutant worms fail to induce expression of gcs-1::gfp upon PA14 infection (Fig 3C-3E). These data, in combination with the microarray (Fig 1E), indicate that fshr-1 is required for the early activation of the host's protective oxidative stress response upon infection. | |||
Detection_method | Construct | |||
Transgene | ||||
Regulation_level | Transcriptional | |||
Regulation_result | Positive_regulate | Anatomy_term | WBbt:0005792 | |
Paper | WBPaper00048530 |