WormBase Tree Display for Interaction: WBInteraction000524336
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| WBInteraction000524336 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00006766 | Interactor_type | Trans_regulator | |
| WBGene00006762 | Interactor_type | Trans_regulated | |||
| Variation_interactor | WBVar00143328 | Interactor_type | Trans_regulator | ||
| Interaction_summary | To determine the specificity of Pitx2 activation of unc-25/GAD, unc-30(e596) worms were co-injected with the Punc-30::Pitx2 expression con- struct along with either a wild-type Punc-25::GFP reporter or a mutant Punc-25::GFP reporter in which the UNC-30 binding sites were altered to CG-rich sequences. GFP expression was only detected from the wild type unc-25 reporter, supporting that Pitx2 transactivation is dependent on intact UNC-30 binding sites in the unc-25/GAD promoter. | ||||
| Regulation_level | Transcriptional | ||||
| Paper | WBPaper00004839 |
