WormBase Tree Display for Interaction: WBInteraction000502389
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| WBInteraction000502389 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00003024 | Interactor_type | Trans_regulated | |
| Expr_pattern | Expr3876 | ||||
| Transgene | WBTransgene00000393 | ||||
| Construct | WBCnstr00000393 | ||||
| WBGene00002990 | Interactor_type | Trans_regulator | |||
| Variation_interactor | WBVar00144296 | Interactor_type | Trans_regulator | ||
| Interaction_summary | When lin-39 transgene deIs6, which showed P6.px GFP expression in 60% of animals, was introduced into a lin-1(e1777) loss-of-function background, in which all the VPCs adopt vulval fates, the GFP expression domain was expanded to all six VPCs. However, GFP expression in P6.px was significantly reduced compared to deIs6 (7% vs. 60%). | ||||
| Detection_method | Construct | ||||
| Reporter_gene | [lin-39::pes-10::gfp], transcriptional fusion | ||||
| Transgene | |||||
| Regulation_level | Transcriptional | ||||
| Regulation_result | Positive_regulate | Anatomy_term | WBbt:0008125 | ||
| Paper | WBPaper00027690 | ||||
| Remark | LIN-1 acts as a negative regulator in VPCs other than P6.p. LIN-1 also functions positively on lin-39 expression in P6.p. lin-39 could be a direct target of LIN-1 in the VPCs. |
