WormBase Tree Display for Interaction: WBInteraction000501964
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| WBInteraction000501964 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00001595 | Interactor_type | Trans_regulated | |
| Expr_pattern | Expr582 | ||||
| Antibody | WBAntibody00000133 | ||||
| WBGene00001609 | Interactor_type | Trans_regulator | |||
| Variation_interactor | WBVar00095073 | Interactor_type | Trans_regulator | ||
| WBVar00241024 | Interactor_type | Trans_regulator | |||
| Interaction_summary | Animals with one copy of the gain-of-function allele glp-1(oz112) and one copy of the glp-1(q175) null allele have a late onset tumorous phenotype where the distal proliferative zone increases in size over time, reflecting constitutive GLP-1 activity. In these animals, low GLD-1 levels extend much further proximally than in wild-type. Therefore, GLP-1/Notch signaling activity leads to low GLD-1 levels, suggesting that in wild-type animals, GLP-1/Notch signaling inhibits GLD-1 accumulation in the distal end. | ||||
| Detection_method | Antibody | ||||
| Regulation_level | Post_transcriptional | ||||
| Regulation_result | Negative_regulate | Anatomy_term | WBbt:0005374 | ||
| Paper | WBPaper00006369 |
