ZK1236.9 encodes a protein with no obvious non-nematode homologs; eitherZK1236.9, or ZK1236.5, or both proteins weakly inhibit DHC-1 in vivo; likewise, either ZK1236.9, or ZK1236.5, or both proteins are required inmass RNAi assays for normal osmoregulation and normally rapid growth.
Enriched in ABplppppap; ABprppppap; intestine; and neurons based on RNA-seq; single-cell RNA-seq; and microarray studies. Is affected by several genes including eat-2; sir-2.1; and pgl-1 based on microarray and RNA-seq studies. Is affected by allantoin; Sirolimus; and Cry5B based on RNA-seq and microarray studies.