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WormBase Tree Display for Gene: WBGene00022356

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Name Class

WBGene00022356SMapS_parentSequenceY92C3A
IdentityVersion2
NameCGC_nameeak-3
Sequence_nameY92C3A.3
Molecular_nameY92C3A.3
Y92C3A.3.1
CE26310
Other_nameCELE_Y92C3A.3Accession_evidenceNDBBX284603
Public_nameeak-3
DB_infoDatabaseAceViewgene3C258
WormQTLgeneWBGene00022356
WormFluxgeneWBGene00022356
NDBlocus_tagCELE_Y92C3A.3
NCBIgene190782
RefSeqproteinNM_064942.2
TREEFAMTREEFAM_IDTF318022
TrEMBLUniProtAccQ9BL23
UniProt_GCRPUniProtAccQ9BL23
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:31:05WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
225 Jan 2008 14:24:07WBPerson2970Name_changeCGC_nameeak-3
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classeak
Allele (50)
StrainWBStrain00003888
RNASeq_FPKM (74)
OrthologWBGene00160227Caenorhabditis brenneriFrom_analysisTreeFam
WBGene00137217Caenorhabditis japonicaFrom_analysisTreeFam
Sp34_40025900Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrIII_pilon.g6893Caenorhabditis elegansFrom_analysisWormBase-Compara
ParalogWBGene00007226
Structured_descriptionConcise_descriptioneak-3 encodes a protein required for the subset of DAF-16 functions controlling dauer development, but not for lifespan regulation; EAK-3 is expressed in XXX cells, and localizes to the plasma membrane, probably by N-terminal myristoylation; EAK-3 acts in a genetic pathway parallel to that of AKT-1, which may include AKT-2, EAK-4, EAK-6, or SDF-9; EAK-3 has no homologs outside of C. elegans itself, has 20% leucine-like residues, and has a single predicted coiled-coil domain; eak-3 mutants have a very weak dauer arrest phenotype at 25 deg. C., but strongly enhance the dauer arrest phenotype of akt-1(mg306), and enhances expression of the DAF-16 target sod-3; eak-3's dauer arrest and sod-3 overexpression phenotypes require DAF-12 and DAF-16; however, EAK-3 has no effect on lifespan.Paper_evidenceWBPaper00027748
WBPaper00031480
Curator_confirmedWBPerson567
Date_last_updated15 Feb 2008 00:00:00
Automated_descriptionExpressed in XXXL and XXXR.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSY92C3A.3
Corresponding_transcriptY92C3A.3.1
Associated_featureWBsf650836
WBsf226184
Experimental_infoRNAi_resultWBRNAi00058622Inferred_automaticallyRNAi_primary
Expr_patternExpr7894
Expr1022833
Expr1039862
Expr1162042
Expr2011146
Expr2029382
Drives_constructWBCnstr00012973
Microarray_results (12)
Expression_cluster (26)
InteractionWBInteraction000009220
WBInteraction000052260
WBInteraction000052261
WBInteraction000052273
WBInteraction000052311
WBInteraction000052337
WBInteraction000052817
WBInteraction000052818
WBInteraction000503471
WBInteraction000503472
Map_infoMapIIIPosition-22.6435Error0.008444
PositivePositive_cloneY92C3AInferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00027748
WBPaper00031480
WBPaper00036004
WBPaper00036472
WBPaper00038936
WBPaper00060179
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene