WormBase Tree Display for Gene: WBGene00022150
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| WBGene00022150 | SMap | S_parent | Sequence | Y71G12B | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | Sequence_name | Y71G12B.10 | |||||||
| Molecular_name | Y71G12B.10 | ||||||||
| Y71G12B.10.1 | |||||||||
| CE26261 | |||||||||
| Other_name | CELE_Y71G12B.10 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | Y71G12B.10 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:05 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Allele (103) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00089108 | ||||||||
| 00089109 | |||||||||
| 00089110 | |||||||||
| 00089111 | |||||||||
| 00089112 | |||||||||
| 00089113 | |||||||||
| 00126327 | |||||||||
| 00126328 | |||||||||
| Contained_in_operon | CEOP1022 | ||||||||
| Ortholog (38) | |||||||||
| Structured_description | Concise_description | Y71G12B.10 encodes a putative 3-hydroxymethyl-3-methylglutaryl-coenzyme A lyase orthologous to human HMG-CoA Lyase (HMGCL). | Paper_evidence | WBPaper00031676 | |||||
| WBPaper00038491 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 25 Jul 2012 00:00:00 | ||||||||
| Automated_description | Predicted to enable hydroxymethylglutaryl-CoA lyase activity. Predicted to be involved in ketone body biosynthetic process and leucine catabolic process. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Is an ortholog of human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase) and HMGCLL1 (3-hydroxy-3-methylglutaryl-CoA lyase like 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9252 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5005) | ||||
| Disease_relevance | Y71G12B.10 is orthologous to human HMG CoA lysase (HMGCL) which catalyzes the cleavage of HMG-CoA to acetoacetic acid and acetyl-CoA, which is the last step of ketogenesis and leucine catabolism; mutations in HMGCL have been associated with HMG-CoA lyase deficiency or Hydroxymethylglutaric aciduria. | Homo sapiens | Accession_evidence | OMIM | 246450 | ||||
| 613898 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 25 Jul 2012 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y71G12B.10 | |||||||
| Corresponding_transcript | Y71G12B.10.1 | ||||||||
| Other_sequence (46) | |||||||||
| Associated_feature | WBsf217244 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00102662 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00058195 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00000233 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1015218 | ||||||||
| Expr1039756 | |||||||||
| Expr1161613 | |||||||||
| Expr2008297 | |||||||||
| Expr2026537 | |||||||||
| Microarray_results (17) | |||||||||
| Expression_cluster (92) | |||||||||
| Interaction (93) | |||||||||
| Map_info | Positive | Positive_clone | Y71G12B | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
| Interpolated_map_position | I | -12.9708 | |||||||
| Reference | WBPaper00026800 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00042257 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00062388 | |||||||||
| Method | Gene |
