WormBase Tree Display for Gene: WBGene00021752
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| WBGene00021752 | SMap | S_parent | Sequence | Y50D7A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | xpd-1 | Paper_evidence | WBPaper00037879 | |||||
| Sequence_name | Y50D7A.2 | ||||||||
| Molecular_name | Y50D7A.2 | ||||||||
| Y50D7A.2.1 | |||||||||
| CE52547 | |||||||||
| Other_name | Y50D7A.d | Curator_confirmed | WBPerson1983 | ||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| Y50D7A.h | |||||||||
| CELE_Y50D7A.2 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | xpd-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:04 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 21 Jul 2014 15:41:21 | WBPerson2970 | Name_change | CGC_name | xpd-1 | ||||
| 3 | 24 Nov 2017 12:02:54 | WBPerson1983 | Event | Acquires_merge | WBGene00021759 | ||||
| Acquires_merge | WBGene00021759 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | xpd | ||||||||
| Allele (375) | |||||||||
| Strain | WBStrain00055485 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (25) | |||||||||
| Contained_in_operon | CEOP3851 | ||||||||
| CEOP3020 | |||||||||
| Ortholog (39) | |||||||||
| Paralog | WBGene00001049 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00009124 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00010839 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00044493 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| Structured_description | Automated_description | Predicted to enable DNA helicase activity and damaged DNA binding activity. Predicted to be involved in positive regulation of mitotic recombination and transcription by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; gastrointestinal system cancer (multiple); hematologic cancer (multiple); and reproductive organ cancer (multiple). Is an ortholog of human ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit). | Paper_evidence | WBPaper00065943 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (31) | ||||||||
| Disease_relevance | Mutations in human ERCC2 (orthologous to elegans Y50D7A.2 and yeast RAD3 genes) are associated with Cerebrooculofacioskeletal syndrome, Trichothiodystrophy and Xeroderma pigmentosum; ERCC2 is involved in DNA excision repair, with putative 5''-3'' DNA helicase activity, and may play a role in aging. | Homo sapiens | Accession_evidence | OMIM | 610756 | ||||
| 601675 | |||||||||
| 278730 | |||||||||
| 126340 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 30 May 2012 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y50D7A.2 | |||||||
| Corresponding_CDS_history | Y50D7A.2:wp99 | ||||||||
| Y50D7A.2:wp262 | |||||||||
| Y50D7A.2:wp263 | |||||||||
| Corresponding_transcript | Y50D7A.2.1 | ||||||||
| Other_sequence (38) | |||||||||
| Associated_feature | WBsf991019 | ||||||||
| WBsf991020 | |||||||||
| WBsf991021 | |||||||||
| WBsf991022 | |||||||||
| WBsf1014036 | |||||||||
| WBsf1014037 | |||||||||
| WBsf1014038 | |||||||||
| WBsf1014039 | |||||||||
| WBsf224355 | |||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern | Expr1011824 | ||||||||
| Expr1023886 | |||||||||
| Expr1039535 | |||||||||
| Expr1039542 | |||||||||
| Expr1160532 | |||||||||
| Expr1160535 | |||||||||
| Expr2007753 | |||||||||
| Expr2018103 | |||||||||
| Expr2025996 | |||||||||
| Expr2036241 | |||||||||
| Microarray_results (29) | |||||||||
| Expression_cluster (95) | |||||||||
| Interaction (166) | |||||||||
| Map_info | Positive | Positive_clone | Y50D7A | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
| Interpolated_map_position | III | -26.9046 | |||||||
| Reference | WBPaper00027223 | ||||||||
| WBPaper00029038 | |||||||||
| WBPaper00031224 | |||||||||
| WBPaper00032410 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00062203 | |||||||||
| Method | Gene |
