WormBase Tree Display for Gene: WBGene00021354
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| WBGene00021354 | SMap | S_parent | Sequence | Y37E3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | fpn-1.1 | |||||||
| Sequence_name | Y37E3.16 | ||||||||
| Molecular_name | Y37E3.16 | ||||||||
| Y37E3.16.1 | |||||||||
| CE36732 | |||||||||
| Other_name | CELE_Y37E3.16 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | fpn-1.1 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00021354 | |||||
| WormFlux | gene | WBGene00021354 | |||||||
| NDB | locus_tag | CELE_Y37E3.16 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00021354|UniProtKB=Q8IA95 | |||||||
| family | PTHR11660 | ||||||||
| NCBI | gene | 171773 | |||||||
| RefSeq | protein | NM_001037896.4 | |||||||
| TREEFAM | TREEFAM_ID | TF313463 | |||||||
| TrEMBL | UniProtAcc | Q8IA95 | |||||||
| UniProt_GCRP | UniProtAcc | Q8IA95 | |||||||
| OMIM | gene | 604653 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:04 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 26 Feb 2008 14:53:11 | WBPerson2970 | Name_change | CGC_name | fpn-1.1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | fpn | ||||||||
| Allele (115) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00084031 | ||||||||
| 00084032 | |||||||||
| 00084033 | |||||||||
| 00084034 | |||||||||
| 00084035 | |||||||||
| 00084036 | |||||||||
| 00125733 | |||||||||
| 00125734 | |||||||||
| 00125735 | |||||||||
| Ortholog (29) | |||||||||
| Paralog | WBGene00019977 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Automated_description | Predicted to enable iron ion transmembrane transporter activity. Predicted to be involved in iron ion transmembrane transport. Predicted to be located in membrane. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in hemochromatosis type 4. Is an ortholog of human SLC40A1 (solute carrier family 40 member 1). | Paper_evidence | WBPaper00065943 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00046532 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 May 2015 00:00:00 | ||||||||
| Potential_model | DOID:0111028 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10909) | |||||
| Disease_relevance | Parkinson''s disease (PD) is a common neurodegenerative disorder, characterized by selective dopaminergic (DAergic) neuron loss in the brain; symptoms include rigidity, tremors and postural instability that are often preceded by emotional instability and cognitive dysfunction; several genes confer risk for autosomal recessive PD, including the parkin/PARK2 gene that encodes for the E3 ubiquitin ligase Parkin; the heavy metal manganese (Mn) is an environmental risk factor for the development of PD; studies in C. elegans have shown significantly increased Mn accumulation in pdr-1/parkin mutants compared to wild-type animals and significant downregulation in mRNA levels of the putative manganese exporter ferroportin, fpn-1.1; overexpression of fpn-1.1 in a pdr-1 mutant strain showed suppression of Mn-induced lethality, decreased levels of pro-oxidant metals like iron and copper, and improved mitochondrial and DAergic integrity and function; these studies reveal the role of Parkin in regulating metal homeostasis. | Homo sapiens | Paper_evidence | WBPaper00046532 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 May 2015 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000348 | ||||||||
| Molecular_info | Corresponding_CDS | Y37E3.16 | |||||||
| Corresponding_CDS_history | Y37E3.16a:wp145 | ||||||||
| Y37E3.16b:wp124 | |||||||||
| Y37E3.16b:wp145 | |||||||||
| Corresponding_transcript | Y37E3.16.1 | ||||||||
| Other_sequence | Acan_isotig11720 | ||||||||
| Dviv_isotig18149 | |||||||||
| FE914595.1 | |||||||||
| HC01962 | |||||||||
| Oden_isotig19140 | |||||||||
| Associated_feature | WBsf648959 | ||||||||
| WBsf219010 | |||||||||
| WBsf219011 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00055933 | Inferred_automatically | RNAi_primary | |||||
| Expr_pattern | Expr1024007 | ||||||||
| Expr1039322 | |||||||||
| Expr1159451 | |||||||||
| Expr2011875 | |||||||||
| Expr2030113 | |||||||||
| Microarray_results (17) | |||||||||
| Expression_cluster (145) | |||||||||
| WBProcess | WBbiopr:00000096 | ||||||||
| Map_info | Map | I | Position | -11.481 | Error | 0.162678 | |||
| Positive | Positive_clone | Y37E3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00038491 | ||||||||
| WBPaper00040349 | |||||||||
| WBPaper00046532 | |||||||||
| WBPaper00048451 | |||||||||
| WBPaper00049884 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
