W06E11.4 encodes an ortholog of human SBDS (OMIM:607444, mutated in Shwachman-Bodian-Diamond syndrome) and S. cerevisiae Sdo1p, that is required for the extended lifespan of daf-2(e1370) mutants; W06E11.4 is expressed ubiquitously (or nearly so) in somatic larval and adult tissues; by orthology with yeast Sdo1p, W06E11.4 is predicted to be a nucleolar protein required for maturation of 60S ribosomal subunits; W06E11.4 shares an operon with tag-266 and T19C3.7.
Predicted to be involved in cytosolic ribosome assembly. Predicted to be located in cytoplasm; nuclear lumen; and spindle. Human ortholog(s) of this gene implicated in Shwachman-Diamond syndrome and aplastic anemia. Is an ortholog of human SBDS (SBDS ribosome maturation factor).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.