WormBase Tree Display for Gene: WBGene00020891
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WBGene00020891 | SMap | S_parent | Sequence | T28C12 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | cest-24 | Person_evidence | WBPerson36909 | |||
WBPerson7188 | |||||||
Sequence_name | T28C12.4 | ||||||
Molecular_name | T28C12.4a | ||||||
T28C12.4a.1 | |||||||
CE14343 | |||||||
T28C12.4b | |||||||
CE14345 | |||||||
T28C12.4a.2 | |||||||
T28C12.4b.1 | |||||||
T28C12.4b.2 | |||||||
Other_name | CELE_T28C12.4 | Accession_evidence | NDB | BX284605 | |||
Public_name | cest-24 | ||||||
DB_info | Database (12) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | cest | ||||||
Allele (128) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00028487 | ||||||
00028488 | |||||||
00028489 | |||||||
00028490 | |||||||
Ortholog (36) | |||||||
Paralog (41) | |||||||
Structured_description | Concise_description | T28C12.4 encodes a protein with visible similarity to human neuroligin 4 (mutated in autism), but also belongs to a large family of carboxylesterases that happen to include NLG-1; normally, T28C12.4 is expressed in hypodermal cells; transcription of T28C12.4 is immediately induced by exposure to ethanol, and with glr-2 is one of a few genes that may be specifically responsive to ethanol (as opposed to other stresses, which are expected to typically induce heat shock genes); the 5' flank of T28C12.4 contains a single ethanol- and stress-responsive element that is required in a T28C12.4::GFP transgene for transcriptional induction by ethanol. | Paper_evidence | WBPaper00006465 | |||
Curator_confirmed | WBPerson567 | ||||||
Date_last_updated | 11 Feb 2007 00:00:00 | ||||||
Automated_description | Predicted to enable carboxylic ester hydrolase activity. Expressed in hypodermis and seam cell. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Disease_relevance | Human liver carboxylesterases, CES1, CES2 and CES3 (orthologous to C. elegans T28C12.4), metabolize and detoxify drugs and toxins; CESs metabolize ester, thioester, carbamate and amide compounds to acid, alcohol and amine products; mutations in CES1 are associated with Carboxylesterase 1 deficiency. | Homo sapiens | Accession_evidence | OMIM | 114835 | |
605278 | |||||||
605279 | |||||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 26 Jun 2012 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | T28C12.4a | |||||
T28C12.4b | |||||||
Corresponding_transcript | T28C12.4a.1 | ||||||
T28C12.4a.2 | |||||||
T28C12.4b.1 | |||||||
T28C12.4b.2 | |||||||
Other_sequence (41) | |||||||
Associated_feature | WBsf646872 | ||||||
WBsf646873 | |||||||
WBsf661326 | |||||||
WBsf661327 | |||||||
WBsf661328 | |||||||
WBsf661329 | |||||||
WBsf1000225 | |||||||
WBsf1000226 | |||||||
WBsf231867 | |||||||
WBsf231868 | |||||||
Experimental_info | RNAi_result | WBRNAi00054391 | Inferred_automatically | RNAi_primary | |||
WBRNAi00019384 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00089171 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00036074 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr2907 | ||||||
Expr1019072 | |||||||
Expr1039101 | |||||||
Expr1157938 | |||||||
Expr2006605 | |||||||
Expr2024821 | |||||||
Drives_construct | WBCnstr00011018 | ||||||
WBCnstr00024806 | |||||||
Construct_product | WBCnstr00024806 | ||||||
Microarray_results (25) | |||||||
Expression_cluster (203) | |||||||
Interaction | WBInteraction000009775 | ||||||
WBInteraction000028826 | |||||||
WBInteraction000029625 | |||||||
WBInteraction000029644 | |||||||
WBInteraction000030923 | |||||||
WBInteraction000032390 | |||||||
WBInteraction000138032 | |||||||
WBInteraction000199571 | |||||||
WBInteraction000224353 | |||||||
WBInteraction000247249 | |||||||
WBInteraction000253180 | |||||||
WBInteraction000253218 | |||||||
WBInteraction000272504 | |||||||
WBInteraction000273237 | |||||||
WBInteraction000295041 | |||||||
WBInteraction000312117 | |||||||
WBInteraction000330512 | |||||||
WBInteraction000341915 | |||||||
WBInteraction000346507 | |||||||
WBInteraction000347331 | |||||||
WBInteraction000361540 | |||||||
WBInteraction000362644 | |||||||
WBInteraction000376062 | |||||||
WBInteraction000381809 | |||||||
WBInteraction000403785 | |||||||
WBInteraction000405085 | |||||||
WBInteraction000410775 | |||||||
WBInteraction000429295 | |||||||
WBInteraction000437934 | |||||||
WBInteraction000438270 | |||||||
WBInteraction000501508 | |||||||
WBInteraction000508888 | |||||||
WBInteraction000515624 | |||||||
Map_info | Map | V | Position | -0.18384 | |||
Positive | Positive_clone | T28C12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference | WBPaper00006465 | ||||||
WBPaper00010030 | |||||||
WBPaper00016665 | |||||||
WBPaper00032322 | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |