WormBase Tree Display for Gene: WBGene00020838
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| WBGene00020838 | SMap | S_parent | Sequence | T27A3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | trak-1 | Person_evidence | WBPerson260 | |||||
| Sequence_name | T27A3.1 | ||||||||
| Molecular_name | T27A3.1a | ||||||||
| T27A3.1a.1 | |||||||||
| CE53790 | |||||||||
| T27A3.1c | |||||||||
| CE33190 | |||||||||
| T27A3.1d | |||||||||
| CE33191 | |||||||||
| T27A3.1c.1 | |||||||||
| T27A3.1d.1 | |||||||||
| Other_name | CELE_T27A3.1 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | trak-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:03 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 09 Dec 2014 15:51:17 | WBPerson2970 | Name_change | CGC_name | trak-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | trak | ||||||||
| Allele (49) | |||||||||
| Strain | WBStrain00054927 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00051225 | ||||||||
| 00051226 | |||||||||
| 00051227 | |||||||||
| 00051228 | |||||||||
| 00051229 | |||||||||
| 00051230 | |||||||||
| 00051231 | |||||||||
| 00051232 | |||||||||
| Ortholog (42) | |||||||||
| Structured_description | Concise_description | T27A3.1 encodes, by alternative splicing, five isoforms of an ortholog of human TRAK1, HAP1 and TRAK2 and of Drosophila MILTON; T27A3.1 is expressed in some chemosensory neurons (ASK, ASI, ADF, and ASE), phasmid neurons (PHB), and CAN neurons; T27A3.1 is also expressed in pharyngeal muscle, epithelial intestinal cells, seam cells, vulva, distal tip cells and the distal sheath cell pair 1, male bilateral sensory rays and spicules, and tail cells; the N-terminal 250-300 residues of T27A3.1 are predicted to encode a highly conserved coiled-coil domain; T27A3.1(RNAi) animals have no obvious phenotypes. | Paper_evidence | WBPaper00031987 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 14 Jul 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable myosin binding activity. Predicted to be involved in mitochondrion distribution; protein targeting; and vesicle transport along microtubule. Predicted to be located in cytoplasmic vesicle and mitochondrion. Expressed in several structures, including CAN; amphid neurons; hermaphrodite somatic gonadal cell; phasmid sensillum; and rectum. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 68. Is an ortholog of human TRAK1 (trafficking kinesin protein 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0112204 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:29947) | ||||
| Disease_relevance | C. elegans T27A3.1 is orthologous to human trafficking kinesin-binding protein 1(TRAK1), trafficking kinesin-binding protein 2 (TRAK2) and Huntington-associated protein 1 (HAP1); HAP1 is known to bind to the Huntington protein, mutant forms which are associated with Huntington disease. | Homo sapiens | Accession_evidence | OMIM | 608112 | ||||
| 600947 | |||||||||
| 607334 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 25 Jun 2012 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T27A3.1a | |||||||
| T27A3.1c | |||||||||
| T27A3.1d | |||||||||
| Corresponding_CDS_history | T27A3.1a:wp274 | ||||||||
| T27A3.1b:wp274 | |||||||||
| T27A3.1e:wp274 | |||||||||
| Corresponding_transcript | T27A3.1a.1 | ||||||||
| T27A3.1c.1 | |||||||||
| T27A3.1d.1 | |||||||||
| Other_sequence (13) | |||||||||
| Associated_feature (11) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00106793 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00106794 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00004314 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00117097 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00075803 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00000337 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00054259 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00002415 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr8171 | ||||||||
| Expr8172 | |||||||||
| Expr8173 | |||||||||
| Expr1022483 | |||||||||
| Expr1039083 | |||||||||
| Expr1157806 | |||||||||
| Expr2017479 | |||||||||
| Expr2035618 | |||||||||
| Drives_construct | WBCnstr00013156 | ||||||||
| WBCnstr00013157 | |||||||||
| WBCnstr00013158 | |||||||||
| WBCnstr00024848 | |||||||||
| Construct_product | WBCnstr00024848 | ||||||||
| Microarray_results (46) | |||||||||
| Expression_cluster (128) | |||||||||
| Interaction (79) | |||||||||
| Map_info | Map | I | Position | 0.789029 | |||||
| Positive | Positive_clone | T27A3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00025960 | ||||||||
| WBPaper00031865 | |||||||||
| WBPaper00031987 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00049738 | |||||||||
| WBPaper00050283 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00060838 | |||||||||
| WBPaper00061025 | |||||||||
| WBPaper00064339 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
