WormBase Tree Display for Gene: WBGene00020658
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WBGene00020658 | SMap | S_parent | Sequence | T21F4 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | argn-1 | Person_evidence | WBPerson2241 | |||||
Sequence_name | T21F4.1 | ||||||||
Molecular_name | T21F4.1 | ||||||||
T21F4.1.1 | |||||||||
CE33700 | |||||||||
T21F4.1.2 | |||||||||
Other_name | CELE_T21F4.1 | Accession_evidence | NDB | BX284606 | |||||
Public_name | argn-1 | ||||||||
DB_info | Database (12) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 28 May 2004 13:31:03 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
2 | 02 Mar 2020 15:36:25 | WBPerson1983 | Name_change | CGC_name | argn-1 | ||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | argn | ||||||||
Allele (34) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation | 00002787 | ||||||||
00002788 | |||||||||
00002789 | |||||||||
00002790 | |||||||||
00002791 | |||||||||
00002792 | |||||||||
00002793 | |||||||||
00002794 | |||||||||
00125239 | |||||||||
Ortholog (36) | |||||||||
Structured_description | Concise_description | T21F4.1 is orthologous to the human gene Arginase Type I Erythroid Variant (ARG1), which contributes most of the arginase activity in the liver. | Paper_evidence | WBPaper00038491 | |||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson1823 | |||||||||
WBPerson567 | |||||||||
Date_last_updated | 19 Jun 2012 00:00:00 | ||||||||
Automated_description | Predicted to enable arginase activity and manganese ion binding activity. Involved in innate immune response. Predicted to be located in cytosol. Expressed in hypodermal cell. Used to study hyperargininemia. Human ortholog(s) of this gene implicated in several diseases, including colitis; hepatocellular carcinoma; and hyperargininemia. Is an ortholog of human ARG1 (arginase 1) and ARG2 (arginase 2). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Experimental_model | DOID:9278 | Homo sapiens | Paper_evidence | WBPaper00059575 | ||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 09 Jun 2021 00:00:00 | ||||||||
Potential_model | DOID:9278 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:663) | |||||
DOID:2841 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:663,HGNC:664) | ||||||
DOID:0060180 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:663) | ||||||
DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:663) | ||||||
Disease_relevance | Mutations in the human gene Arginase Type I Erythroid Variant (ARG1; orthologous to elegans T21F4.1), which contributes most of the arginase activity in the liver leads to argininemia, which is an autosomal recessive metabolic disorder; ARG1 catalyses the last step in the urea cycle. | Homo sapiens | Accession_evidence | OMIM | 608313 | ||||
207800 | |||||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 19 Jun 2012 00:00:00 | ||||||||
Models_disease_in_annotation | WBDOannot00000944 | ||||||||
Models_disease_asserted | WBDOannot00000943 | ||||||||
Molecular_info | Corresponding_CDS | T21F4.1 | |||||||
Corresponding_CDS_history | T21F4.1:wp97 | ||||||||
T21F4.1:wp225 | |||||||||
T21F4.1a:wp259 | |||||||||
T21F4.1b:wp259 | |||||||||
Corresponding_transcript | T21F4.1.1 | ||||||||
T21F4.1.2 | |||||||||
Other_sequence (50) | |||||||||
Associated_feature (12) | |||||||||
Experimental_info | RNAi_result | WBRNAi00018988 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00053755 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr16081 | ||||||||
Expr16082 | |||||||||
Expr1029161 | |||||||||
Expr1038997 | |||||||||
Expr1157304 | |||||||||
Expr2006332 | |||||||||
Expr2024552 | |||||||||
Drives_construct | WBCnstr00042752 | ||||||||
WBCnstr00042753 | |||||||||
Construct_product | WBCnstr00042753 | ||||||||
Microarray_results (21) | |||||||||
Expression_cluster (199) | |||||||||
Interaction (48) | |||||||||
Map_info | Positive | Positive_clone | T21F4 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
Interpolated_map_position | X | -4.42625 | |||||||
Reference (3) | |||||||||
Method | Gene |