WormBase Tree Display for Gene: WBGene00018783

WBGene00018783 SMap: S_parent: Sequence: F54A3
  Identity: Version: 2
    Name: CGC_name: cbs-2 Paper_evidence: WBPaper00039977
          Person_evidence: WBPerson537
      Sequence_name: F54A3.4
      Molecular_name: F54A3.4
        F54A3.4.1
        CE47819
      Other_name: F54A3.d Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        F54A3.e Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CELE_F54A3.4 Accession_evidence: NDB BX284602
      Public_name: cbs-2
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:00 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 29 Sep 2011 10:45:56 WBPerson2970 Name_change: CGC_name: cbs-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cbs
    Allele: WBVar00710490
      WBVar00710491
      WBVar02097596
      WBVar00710492
      WBVar01499702
      WBVar00710493
      WBVar00069810
      WBVar00710494
      WBVar00710495
      WBVar02120604
      WBVar00710496
      WBVar02123182
      WBVar00710497
      WBVar01988837
      WBVar00710498
      WBVar00710499
      WBVar01988838
      WBVar00710500
      WBVar00710501
      WBVar00710502
      WBVar00710503
      WBVar00710504
      WBVar02113436
      WBVar00710505
      WBVar00710506
      WBVar01362972
      WBVar02123007
      WBVar00710507
      WBVar02121537
      WBVar00710508
      WBVar00710509
      WBVar00710510
      WBVar00710511
      WBVar00710512
      WBVar02086209
      WBVar02086210
      WBVar02122097
      WBVar00358768
      WBVar00358769
      WBVar00358770
      WBVar00358771
      WBVar00358772
      WBVar00358773
      WBVar00358774
      WBVar02035397
      WBVar00358775
      WBVar02035398
      WBVar00358776
      WBVar00358777
      WBVar01500106
      WBVar00100244
      WBVar00100245
      WBVar00100246
      WBVar01900543
      WBVar01624751
      WBVar02124326
      WBVar01624752
      WBVar01624753
      WBVar01624754
      WBVar01624755
      WBVar01624756
      WBVar02014300
      WBVar02121946
      WBVar01232176
      WBVar01232177
      WBVar01232181
      WBVar01546338
      WBVar01232182
      WBVar01232183
      WBVar02084411
      WBVar01546339
      WBVar01232184
      WBVar02084412
      WBVar01546340
      WBVar01546341
      WBVar02084413
      WBVar01232186
      WBVar02084414
      WBVar02151492
      WBVar02151681
      WBVar02101903
      WBVar01339486
      WBVar02124543
      WBVar02122524
      WBVar02106328
      WBVar02091977
      WBVar02091978
      WBVar02091979
      WBVar01494453
      WBVar02116826
      WBVar02028840
      WBVar01933781
      WBVar01436358
      WBVar01436359
      WBVar01436361
      WBVar01685144
      WBVar02108572
      WBVar02108573
      WBVar00233879
      WBVar00546189
      WBVar00233880
      WBVar00546190
      WBVar00546191
      WBVar01718378
      WBVar01718379
      WBVar01718380
      WBVar01535643
      WBVar02151738
      WBVar01535644
      WBVar01789219
      WBVar01535645
      WBVar01789220
      WBVar01789221
      WBVar01535646
      WBVar01789222
      WBVar01764448
      WBVar01535647
      WBVar01891516
      WBVar01535648
      WBVar01764449
      WBVar01535649
      WBVar01535650
      WBVar01535651
      WBVar01535652
      WBVar01535653
      WBVar01535654
      WBVar01535655
      WBVar01535656
      WBVar01535657
      WBVar01535658
      WBVar01603072
      WBVar01535659
      WBVar01535660
      WBVar01535661
      WBVar01535662
      WBVar01535663
      WBVar02122773
      WBVar01535664
      WBVar02006909
      WBVar01535665
      WBVar00069765
      WBVar00166508
      WBVar02121124
      WBVar00166509
      WBVar00069770
      WBVar01392910
      WBVar00166510
      WBVar01959355
      WBVar00166511
      WBVar00166512
      WBVar00091950
      WBVar00166513
      WBVar00069775
      WBVar02114320
      WBVar00069780
      WBVar00069785
      WBVar00710477
      WBVar02095558
      WBVar00710478
      WBVar00069790
      WBVar02102918
      WBVar00710479
      WBVar00710480
      WBVar00710481
      WBVar00069795
      WBVar00710482
      WBVar00710483
      WBVar02122433
      WBVar02120776
      WBVar00710484
      WBVar00069800
      WBVar00710485
      WBVar00710486
      WBVar00710487
      WBVar00710488
      WBVar00069805
      WBVar00710489
    Strain: WBStrain00031552
    RNASeq_FPKM (74)
    GO_annotation (11)
    Contained_in_operon: CEOP2708
    Ortholog (23)
    Paralog (12)
    Structured_description: Concise_description: The F54A3.4 gene encodes a homolog of the human gene CBS, which when mutated leads to homocystinuria (OMIM:236200). Paper_evidence: WBPaper00004637
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable cystathionine beta-synthase activity. Predicted to be involved in cysteine biosynthetic process from serine. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including homocystinuria; hyperhomocysteinemia; and neural tube defect. Is an ortholog of human CBS (cystathionine beta-synthase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0080074 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1550)
      DOID:12365 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1550)
      DOID:9279 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1550)
      DOID:9263 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1550)
      DOID:3526 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1550)
      DOID:3393 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1550)
  Molecular_info: Corresponding_CDS: F54A3.4
    Corresponding_CDS_history: F54A3.4:wp233
    Corresponding_transcript: F54A3.4.1
    Other_sequence (18)
  Experimental_info: RNAi_result: WBRNAi00048206 Inferred_automatically: RNAi_primary
      WBRNAi00015558 Inferred_automatically: RNAi_primary
      WBRNAi00048207 Inferred_automatically: RNAi_primary
      WBRNAi00015557 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1026794
      Expr1038097
      Expr1152016
      Expr2009745
      Expr2027985
    Microarray_results (12)
    Expression_cluster (167)
    Interaction (85)
  Map_info: Map: II Position: -13.8397 Error: 0.00061
    Positive: Positive_clone: F54A3 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00039977
    WBPaper00040475
    WBPaper00040626
    WBPaper00055090
    WBPaper00059856
    WBPaper00060693
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene