WormBase Tree Display for Gene: WBGene00018514
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| WBGene00018514 | SMap | S_parent | Sequence | F46G11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | twnk-1 | |||||||
| Sequence_name | F46G11.1 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | CELE_F46G11.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | twnk-1 | ||||||||
| DB_info | Database | AceView | gene | XG415 | |||||
| WormQTL | gene | WBGene00018514 | |||||||
| WormFlux | gene | WBGene00018514 | |||||||
| NDB | locus_tag | CELE_F46G11.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00018514|UniProtKB=A0A3P6N6A0 | |||||||
| family | PTHR12873 | ||||||||
| NCBI | gene | 180845 | |||||||
| RefSeq | protein | NM_001383588.2 | |||||||
| NM_001368518.5 | |||||||||
| NM_001380982.1 | |||||||||
| NM_076572.6 | |||||||||
| TrEMBL | UniProtAcc | A0A3P6PCZ1 | |||||||
| A0A3P6N6A0 | |||||||||
| A0A3P6NIH1 | |||||||||
| Q5WRT0 | |||||||||
| UniProt_GCRP | UniProtAcc | A0A3P6N6A0 | |||||||
| OMIM | gene | 606075 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:00 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 12 Nov 2018 16:28:50 | WBPerson1983 | Name_change | CGC_name | twnk-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | twnk | ||||||||
| Allele (110) | |||||||||
| Strain | WBStrain00037458 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Ortholog (36) | |||||||||
| Structured_description | Concise_description | F46G11.1 is orthologous to the human gene TRUNCATED PUTATIVE T7-LIKE MITOCHONDRIAL DNA HELICASE (C10orf2; OMIM:606075), which when mutated leads to disease. | Curator_confirmed | WBPerson1823 | |||||
| WBPerson567 | |||||||||
| Date_last_updated | 06 Aug 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable 5'-3' DNA helicase activity and single-stranded DNA binding activity. Predicted to be involved in mitochondrial DNA replication. Predicted to be located in mitochondrial nucleoid. Human ortholog(s) of this gene implicated in Perrault syndrome; autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 3; and mitochondrial DNA depletion syndrome 7. Is an ortholog of human TWNK (twinkle mtDNA helicase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0080126 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1160) | ||||
| DOID:12558 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1160) | ||||||
| DOID:0050857 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1160) | ||||||
| DOID:0111520 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1160) | ||||||
| Molecular_info | Corresponding_CDS | F46G11.1a | |||||||
| F46G11.1b | |||||||||
| F46G11.1c | |||||||||
| F46G11.1d | |||||||||
| Corresponding_CDS_history | F46G11.1:wp108 | ||||||||
| F46G11.1:wp133 | |||||||||
| F46G11.1:wp230 | |||||||||
| Corresponding_transcript | F46G11.1a.1 | ||||||||
| F46G11.1b.1 | |||||||||
| F46G11.1c.1 | |||||||||
| F46G11.1d.1 | |||||||||
| Other_sequence (12) | |||||||||
| Associated_feature | WBsf1005386 | ||||||||
| WBsf1005387 | |||||||||
| WBsf1005388 | |||||||||
| WBsf1005389 | |||||||||
| WBsf1005390 | |||||||||
| WBsf1023010 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00047577 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00075606 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00032392 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00047574 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00015128 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1015186 | ||||||||
| Expr1037977 | |||||||||
| Expr1151411 | |||||||||
| Expr2003815 | |||||||||
| Expr2022035 | |||||||||
| Microarray_results (26) | |||||||||
| Expression_cluster (137) | |||||||||
| Interaction (73) | |||||||||
| Map_info | Map | X | Position | -4.2985 | |||||
| Positive | Positive_clone | F46G11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00038491 | ||||||||
| WBPaper00044697 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00065768 | |||||||||
| WBPaper00065799 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
